ArticleInvestigative ophthalmology & visual science2020
Quasi-Static Optical Coherence Elastography to Characterize Human Corneal Biomechanical Properties.
Article in Investigative ophthalmology & visual science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Regional corneal biomechanics assessment as a function of age using Strain-Stress Index maps.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Review
- Time-dependent changes in corneal biomechanics after small incision lenticule extraction: an in vivo study.BMC ophthalmology · 2025Article
- Analyzing the changing trend of corneal biomechanical properties under different influencing factors in T2DM patients.Scientific reports · 2024Article
- [Characterization of rabbit corneal biomechanical properties after corneal refractive surgery based on rapid loading-unloading uniaxial tensile test].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift.Eye and vision (London, England) · 2023Review
- Review
- Developing Affordable, Portable and Simplistic Diagnostic Sensors to Improve Access to Care.Sensors (Basel, Switzerland) · 2022Article
- Biomechanics of Ophthalmic Crosslinking.Translational vision science & technology · 2021Review
- Static compression optical coherence elastography to measure the mechanical properties of soft contact lenses.Biomedical optics express · 2021Article
- Refractive changes of a new asymmetric intracorneal ring segment with variable thickness and base width: A 2D finite-element model.PloS one · 2021Article
- Heartbeat-Induced Corneal Axial Displacement and Strain Measured by High Frequency Ultrasound Elastography in Human Volunteers.Translational vision science & technology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Quasi-static optical coherence elastography (OCE) is an emerging technology to investigate corneal biomechanical behavior in situations similar to physiological stress conditions. Herein OCE was applied to evaluate previously inaccessible biomechanical characteristics of human corneal tissue and to study the role of Bowman's layer in corneal biomechanics. Methods: Human corneal donor buttons (n = 23) were obtained and Descemet's membrane and endothelium were removed. In 11 corneas, Bowman's layer was ablated by a 20 µm stromal excimer laser ablation. Buttons were mounted on an artificial anterior chamber and subjected to a pressure modulation from 10 to 30 mm Hg, and back to 10 mm Hg, in steps of 1 mm Hg. At each step, a spectral-domain optical coherence tomography scan was obtained. Displacements were analyzed by optical flow tracking, and strain over the entire stromal depth was retrieved from the phase gradient of the complex interference signal. Results: During pressure increase, corneal tissue moved upward (486-585 nm/mm Hg) but did not fully recover (Δ= 2.63 to 8.64 µm) after pressure decrease. Vertical corneal strain distribution was negative in the anterior and positive in the posterior cornea, indicating simultaneous corneal compression and expansion, respectively. Bowman's layer caused minor localized differences in corneal strain distribution. Conclusions: Corneal strain distribution is more complex than previously assumed, with a fundamental difference in mechanical response between the anterior and posterior stroma. Clinically, OCE technology might be used to monitor the progression of corneal ectatic diseases and to determine the success of corneal cross-linking.
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