ArticleJournal of Alzheimer's disease : JAD2020
Diagnostic and Prognostic Accuracy of the Cogstate Brief Battery and Auditory Verbal Learning Test in Preclinical Alzheimer's Disease and Incident Mild Cognitive Impairment: Implications for Defining Subtle Objective Cognitive Impairment.
Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Evaluating digital cognitive tests for clinical use in Alzheimer's disease: A novel framework and scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Early cognitive screening for individuals on the dementia continuum: A novel approach amid current trends.Journal of Alzheimer's disease : JAD · 2026Review
- Influence ofFrontiers in nutrition · 2026Article
- Orbitofrontal Gray-White Interface Injury and the Association of Soccer Heading With Verbal Learning.JAMA network open · 2025Article
- Constipation symptoms are associated with worse cognitive outcomes in older adults without dementia.Frontiers in nutrition · 2025Article
- Predicting amyloid status in mild cognitive impairment: the role of semantic intrusions combined with plasma biomarkers.Frontiers in aging neuroscience · 2025Article
- Stricker Learning Span criterion validity: a remote self-administered multi-device compatible digital word list memory measure shows similar ability to differentiate amyloid and tau PET-defined biomarker groups as in-person Auditory Verbal Learning Test.Journal of the International Neuropsychological Society : JINS · 2024Article
- Detection of cerebrospinal fluid biomarkers changes of Alzheimer's disease using a cognitive stress test in persons with subjective cognitive decline and mild cognitive impairment.Frontiers in psychology · 2024Article
- Unsupervised Online Paired Associates Learning Task from the Cambridge Neuropsychological Test Automated Battery (CANTAB®) in the Brain Health Registry.The journal of prevention of Alzheimer's disease · 2024Article
- Depression Moderates the Relationship between Trait Anxiety, Worry and Attentional Control in Melanoma Survivors.Healthcare (Basel, Switzerland) · 2023Article
- Stress and Right Prefrontal Transcranial Direct Current Stimulation (tDCS) Interactive Effects on Visual Working Memory and Learning.Brain sciences · 2023Article
- Relevance of Minor Neuropsychological Deficits in Patients With Subjective Cognitive Decline.Neurology · 2023Observational
- Influence of amyloid and diagnostic syndrome on non-traditional memory scores in early-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Neural network process simulations support a distributed memory system and aid design of a novel computer adaptive digital memory test for preclinical and prodromal Alzheimer's disease.Neuropsychology · 2023Article
- Chinese version of the auditory verbal learning test: normative study and clinical applications in Chinese-speaking population in Shijiazhuang city.Acta neurologica Belgica · 2023Article
- Current Diagnostic Pathways for Alzheimer's Disease: A Cross-Sectional Real-World Study Across Six Countries.Journal of Alzheimer's disease reports · 2023Article
- Correlation between serum lipid profiles and cognitive impairment in old age: a cross-sectional study.General psychiatry · 2023Article
- Computerized paired associate learning performance and imaging biomarkers in older adults without dementia.Brain imaging and behavior · 2022Article
- Alpha3/alpha2 power ratios relate to performance on a virtual reality shopping task in ageing adults.Frontiers in aging neuroscience · 2022Article
- Unsupervised Performance of the CogState Brief Battery in the Brain Health Registry: Implications for Detecting Cognitive Decline.The journal of prevention of Alzheimer's disease · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere are detectable cognitive differences in cognitively unimpaired (CU) individuals with preclinical Alzheimer's disease (AD).
objectiveTo determine whether cross-sectional performance on the Cogstate Brief Battery (CBB) and Auditory Verbal Learning Test (AVLT) could identify 1) CU participants with preclinical AD defined by neuroimaging biomarkers of amyloid and tau, and 2) incident mild cognitive impairment (MCI)/dementia.
methodCU participants age 50+ were eligible if they had 1) amyloid (A) and tau (T) imaging within two years of their baseline CBB or 2) at least one follow-up visit. AUROC analyses assessed the ability of measures to differentiate groups. We explored the frequency of cross-sectional subtle objective cognitive impairment (sOBJ) defined as performance ≤-1 SD on CBB Learning/Working Memory Composite (Lrn/WM) or AVLT delayed recall using age-corrected normative data.
resultsA+T+ (n = 33, mean age 79.5) and A+T- (n = 61, mean age 77.8) participants were older than A-T- participants (n = 146, mean age 66.3), and comparable on sex and education. Lrn/WM did not differentiate A + T+or A+T- from A-T- participants. AVLT differentiated both A+T+ and A+T- from A-T- participants; 45% of A+T+ and 25% of A+T- participants met sOBJ criteria. The follow-up cohort included 150 CU individuals who converted to MCI/dementia and 450 age, sex, and education matched controls. Lrn/WM and AVLT differentiated between stable and converter CU participants.
conclusionAmong CU participants, AVLT helped differentiate A+T+ and A+T- from A-T- participants. The CBB did not differentiate biomarker subgroups, but showed potential for predicting incident MCI/dementia. Results inform future definitions of sOBJ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.