Evidence map›Paper›PMID 32538839›Full record

ArticleJournal of Alzheimer's disease : JAD2020

Endostatin as a Mediator Between Endothelial Function and Cognitive Performance in Those at Risk for Vascular Cognitive Impairment.

Cameron Isaacs-Trepanier, Mahwesh Saleem, Nathan Herrmann, Walter Swardfager, Paul I Oh, Benjamin I Goldstein, Jane Mitchell, Kim S Sugamori, Krista L Lanctôt

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Cameron Isaacs-TrepanierDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
Mahwesh SaleemDepartment of Psychiatry, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Nathan HerrmannDepartment of Psychiatry, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Walter SwardfagerDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
Paul I OhKITE, UHN-Toronto Rehab, Toronto, Ontario, Canada.
Benjamin I GoldsteinDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
Jane MitchellDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
Kim S SugamoriDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
Krista L LanctôtDepartment of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CASunnybrook Health Science Centre · CASunnybrook Hospital · CAToronto Rehabilitation Institute · CA

Funding

CIHR LANCTOTMOP-114913
6 · The paper itself

Abstract

backgroundPatients with coronary artery disease have an increased risk for developing vascular cognitive impairment. Endothelial function is often diminished and has been associated with lower cognitive performance in these patients. The link between endothelial function and cognition in coronary artery disease is not fully understood. Angiogenesis may play a role in mediating the association between endothelial function and cognition since angiogenic processes rely heavily on the endothelium.

objectiveThe aim of this study was to determine if markers of angiogenesis mediate the relationship between endothelial function and cognition in coronary artery disease patients.

methodsIn 50 participants with coronary artery disease, endothelial function was assessed using peripheral arterial tonometry. Vascular endothelial growth factor (pro-angiogenic) and endostatin (anti-angiogenic) were measured in peripheral serum samples. Cognition was assessed using the Montreal Cognitive Assessment. A mediation analysis, using a bias corrected inferential bootstrapping method with 10,000 permutations, was used to determine if vascular endothelial growth factor or endostatin mediated an association between peripheral arterial tonometry measures and cognitive performance on the Montreal Cognitive Assessment.

resultsEndostatin, but not vascular endothelial growth factor, mediated a relationship between endothelial function and cognitive performance when controlling for total years of education, body mass index, coronary artery bypass graft, stent, diabetes, and diuretic use. This analysis was also significant when delayed recall was substituted for the overall score on the Montreal Cognitive Assessment.

conclusionThese results suggest that endostatin mediates an association between endothelial function and cognitive performance in coronary artery disease.

Indexed as

AgedBiomarkersCognitionCognitive DysfunctionCoronary Artery DiseaseEndostatinsEndothelium, VascularFemaleHumansMaleMiddle AgedPsychomotor PerformanceRisk FactorsVascular Endothelial Growth Factor ABiomarkersEndostatinsVascular Endothelial Growth Factor AVEGFA protein, humanCognitioncognitive dysfunctioncoronary artery diseaseendostatinendotheliumvascular endothelial growth factor

Identifiers

PMID32538839
PMCPMC7458520
OpenAlexW3034828836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.