Evidence map›Paper›PMID 32538572›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2020

[Effect of micro RNA-335-5p regulating bone morphogenetic protein 2 on osteogenic differentiation of human bone marrow mesenchymal stem cells].

Zhenming Huang, Zhuo Cai, Jing Qian, Jianxiong Wang, Ning Hu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. [Content of bone morphogenetic protein 2 in demineralized bone matrix prepared from different long bones and study of the osteogenic propertiesZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zhenming HuangDepartment of Trauma Surgery, the Ninth Hospital of Wuhan City, Wuhan Hubei, 430080, P.R.China.
Zhuo CaiDepartment of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, 430000, P.R.China.
Jing QianDepartment of Trauma Surgery, the Ninth Hospital of Wuhan City, Wuhan Hubei, 430080, P.R.China.
Jianxiong WangDepartment of Trauma Surgery, the Ninth Hospital of Wuhan City, Wuhan Hubei, 430080, P.R.China.
Ning HuDepartment of Orthopaedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400000, P.R.China.
Wuhan No.1 Hospital · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of micro RNA (miR)-335-5p regulating bone morphogenetic protein 2 (BMP-2) on the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs).

methodshBMSCs were cultured

resultsCompared with group A, the relative proportion of ALP positive cells and the relative content of mineralized nodules, the relative expressions of BMP-2, miR-335-5p, OPN, OCN, Runx2 mRNAs, the relative expressions of Runx2, OPN, OCN, and BMP-2 proteins in group B were significantly increased (

conclusionmiR-335-5p can up-regulate BMP-2 expression and promote osteogenic differentiation of hBMSCs.

Indexed as

Bone Marrow CellsGene Expression Regulation, DevelopmentalMesenchymal Stem CellsMicroRNAsOsteogenesisBone Morphogenetic Protein 2Cell DifferentiationCells, CulturedHumansBone Morphogenetic Protein 2MicroRNAsMIRN335 microRNA, humanbone morphogenetic protein 2human bone marrow mesenchymal stem cellsMicro RNA-335-5posteogenic differentiation

Identifiers

PMID32538572
PMCPMC8171532
OpenAlexW3035268849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.