Evidence map›Paper›PMID 32538283›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Cerebral metabolic rate of oxygen during transition from wakefulness to sleep measured with high temporal resolution OxFlow MRI with concurrent EEG.

Alessandra Caporale, Hyunyeol Lee, Hui Lei, Hengyi Rao, Michael C Langham, John A Detre, Pei-Hsin Wu, Felix W Wehrli

Registry-linked trialAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03479203 (Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03479203 early_phase1completednot on this map

Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity

TypeinterventionalSponsorUniversity of PennsylvaniaRan2018 to 2022Enrolled31ConditionsEndothelial Dysfunction, Biochemical MarkersArmsElectronic Cigarette Aerosol
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Cortex-specific inversion of visual responses during sleep.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Validation of a new 3D quantitative BOLD based cerebral oxygen extraction mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  6. Recent Advances in MR Imaging-based Quantification of Brain Oxygen Metabolism.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  7. Article
  8. Review
  9. Superior sagittal sinus flow as a proxy for tracking global cerebral blood flow dynamics during wakefulness and sleep.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  10. Review
  11. MRI evaluation of cerebral metabolic rate of oxygen (CMROJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  12. Article
  13. Sleep, Narcolepsy, and Sodium Oxybate.Current neuropharmacology · 2022
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessandra CaporaleLaboratory for Structural Physiologic and Functional Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, PA, USA.ORCID 0000-0002-2182-8312
Hyunyeol LeeLaboratory for Structural Physiologic and Functional Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, PA, USA.
Hui LeiCenter for Functional Neuroimaging, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Hengyi RaoCenter for Functional Neuroimaging, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Michael C LanghamLaboratory for Structural Physiologic and Functional Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, PA, USA.
John A DetreLaboratory for Structural Physiologic and Functional Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, PA, USA.
Pei-Hsin WuLaboratory for Structural Physiologic and Functional Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, PA, USA.
Felix W WehrliLaboratory for Structural Physiologic and Functional Imaging, Department of Radiology, University of Pennsylvania Perelman School of Medicine, PA, USA.

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
MRI and Serum Markers of Endothelial Stress Resulting from E-Cigarette Aerosol InhalationR01HL139358 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2017 to 2020
$1.9M
Neurometabolic Assessment of Obstructive Sleep Apnea by MRIR01HL122754 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2015 to 2018
$1.7M
NCATS NIH HHS UL1 TR001878NHLBI NIH HHS R01 HL122754NHLBI NIH HHS R01 HL139358
6 · The paper itself

Abstract

During slow-wave sleep, synaptic transmissions are reduced with a concomitant reduction in brain energy consumption. We used 3 Tesla MRI to noninvasively quantify changes in the cerebral metabolic rate of O

Indexed as

MetabolismAdultBrainCerebrovascular CirculationElectroencephalographyFemaleHealthy VolunteersHeart RateHumansMagnetic Resonance ImagingMaleOxygen ConsumptionSleepWakefulnessYoung AdultCerebral metabolismconcurrent EEGsleepvenous saturationwakefulness

Identifiers

PMID32538283
PMCPMC7983504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.