Evidence map›Paper›PMID 32538259›Full record

ArticleInnate immunity2020

Miguel A Zarate, Stephanie R Wesolowski, Leanna M Nguyen, Robyn K De Dios, Randall B Wilkening, Paul J Rozance, Clyde J Wright

Open access · goldAbstract read
In one paragraph

Article in Innate immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Miguel A ZarateSection of Neonatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0003-2389-2892
Stephanie R WesolowskiSection of Neonatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Leanna M NguyenSection of Neonatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Robyn K De DiosSection of Neonatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Randall B WilkeningSection of Neonatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Paul J RozanceSection of Neonatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Clyde J WrightSection of Neonatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Children's Hospital Colorado · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Nutrient Coordination of Pancreatic Vasculature and Beta-CellsR01DK088139 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ROZANCE, PAUL JOSEPH · 2011 to 2020
$5.1M
Physiological Ramifications of Chorionic Somatomammotropin DeficiencyR01HD093701 · NICHD · UNIVERSITY OF COLORADO DENVER · PI ANTHONY, RUSSELL V, ROZANCE, PAUL JOSEPH · 2018 to 2022
$2.9M
Role of hepatic IkBb-mediated sustained NFkB activation in neonatal lung injury and abnormal developmentR01HL132941 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI WRIGHT, CLYDE JASON · 2017 to 2021
$2.3M
NHLBI NIH HHS R01 HL132941NICHD NIH HHS R01 HD093701NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK088139
6 · The paper itself

Abstract

Chorioamnionitis is associated with inflammatory end-organ damage in the fetus. Tissues in direct contact with amniotic fluid drive a pro-inflammatory response and contribute to this injury. However, due to a lack of direct contact with the amniotic fluid, the liver contribution to this response has not been fully characterized. Given its role as an immunologic organ, we hypothesized that the fetal liver would demonstrate an early innate immune response to an

Indexed as

AcidosisAnimalsChorioamnionitisDisease Models, AnimalFemaleFetusGene Expression RegulationHumansHydrocortisoneImmunity, InnateInflammationLipopolysaccharidesLiverMacrophagesNorepinephrinePregnancyHydrocortisoneLipopolysaccharidesNorepinephrineChorioamnionitisfetusinnate immunitylivermacrophages

Identifiers

PMID32538259
PMCPMC7556190
OpenAlexW3035432334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.