Evidence map›Paper›PMID 32538234›Full record

ReviewJournal of the American Heart Association2020

Direct Oral Anticoagulant Use: A Practical Guide to Common Clinical Challenges.

Ashley Chen, Eric Stecker, Bruce A Warden

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06606275 (The Safety and Effectiveness of Warfarin Vs Apixaban in Patients With Non-Valvular Atrial Fibrillation/ Venous Thromboembolism and End-Stage Kidney Disease on Dialysis), which is not on this map. Cited by 352 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
352citing papers in PubMed, 18 pooled it
48.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06606275 completednot on this mapstarted 2024, after this paper: background citation

The Safety and Effectiveness of Warfarin Vs Apixaban in Patients With Non-Valvular Atrial Fibrillation/ Venous Thromboembolism and End-Stage Kidney Disease on Dialysis

TypeobservationalSponsorAbu Dhabi Health Services CompanyRan2024 to 2024Enrolled67ConditionsEnd-Stage Kidney Disease (ESKD), Non-valvular Atrial Fibrillation (NVAF), Venous Thromboembolism (VTE)ArmsApixaban, Warfarin
3 · Its place in the literature

Who cites it

352 citing papers in PubMed, 18 syntheses or guidelines pooled it, 627 citations in OpenAlex.

  1. Pooled it
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  5. Clinical characteristics and outcomes of ischemic stroke despite appropriate oral anticoagulation for atrial fibrillation: A systematic review and meta-analysis of real-world studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  6. Pooled it
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  8. Safety and Efficacy of DOAC Versus VKA in Adult Congenital Heart Disease: A Systematic Review and Meta-Analysis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Pooled it
  9. Guideline
  10. Brazilian guidelines for the pharmacological treatment of pulmonary embolism. Official document of the Brazilian Thoracic Association based on the GRADE methodology.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025
    Guideline
  11. Pooled it
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  14. Risk of bleeding with concomitant use of oral anticoagulants and aspirin: A systematic review and meta-analysis.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2024
    Pooled it
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  19. Trial
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292 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ashley ChenSt. Joseph Medical Center Tacoma WA.
Eric SteckerElectrophysiology Section Knight Cardiovascular Institute Oregon Health & Science University Portland OR.
Bruce A WardenCenter for Preventive Cardiology Knight Cardiovascular Institute Oregon Health & Science University Portland OR.
Oregon Health & Science University · USSt. Joseph Medical Center in Tacoma · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct oral anticoagulants (DOACs) have quickly become attractive alternatives to the long-standing standard of care in anticoagulation, vitamin K antagonist. DOACs are indicated for prevention and treatment of several cardiovascular conditions. Since the first approval in 2010, DOACs have emerged as leading therapeutic alternatives that provide both clinicians and patients with more effective, safe, and convenient treatment options in thromboembolic settings. With the expanding role of DOACs, clinicians are faced with increasingly complex decisions relating to appropriate agent, duration of treatment, and use in special populations. This review will provide an overview of DOACs and act as a practical reference for clinicians to optimize DOAC use among common challenging scenarios. Topics addressed include (1) appropriate indications; (2) use in patients with specific comorbidities; (3) monitoring parameters; (4) transitioning between anticoagulant regimens; (5) major drug interactions; and (6) cost considerations.

Indexed as

Administration, OralBlood CoagulationClinical Decision-MakingComorbidityCost-Benefit AnalysisDrug CostsDrug InteractionsDrug MonitoringDrug SubstitutionFactor Xa InhibitorsHemorrhageHumansRisk AssessmentRisk FactorsTreatment OutcomeFactor Xa Inhibitorsanticoagulationoral direct thrombin inhibitororal factor Xa inhibitorspharmacotherapy

Identifiers

PMID32538234
PMCPMC7670541
OpenAlexW3034331236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.