Evidence map›Paper›PMID 32538088›Full record

ArticleJournal of medicinal chemistry2020

Discovery of Dihydropyrrolo[1,2-

Matthew P Epplin, Ayush Mohan, Lynnea D Harris, Zongjian Zhu, Katie L Strong, John Bacsa, Phuong Le, David S Menaldino, Stephen F Traynelis, Dennis C Liotta

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Matthew P EpplinDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0002-1121-3701
Ayush MohanDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Lynnea D HarrisDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Zongjian ZhuDepartment of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
Katie L StrongDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
John BacsaDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0001-5681-4458
Phuong LeDepartment of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.
David S MenaldinoDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Stephen F TraynelisDepartment of Pharmacology and Chemical Biology, Emory University, 1510 Clifton Road, Atlanta, Georgia 30322, United States.ORCID 0000-0002-3750-9615
Dennis C LiottaDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID 0000-0002-7736-7113
Emory University · US

Funding

Glutamate receptors and human neurological diseaseR35NS111619 · NINDS · EMORY UNIVERSITY · PI Stephen F Traynelis · 2019 to 2026
$6.6M
Mechanism of Action of Novel Subunit-Selective NMDA Receptor ModulatorsR01NS065371 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2009 to 2018
$3.4M
NINDS NIH HHS R01 NS065371NINDS NIH HHS R35 NS111619
6 · The paper itself

Abstract

The

Indexed as

Allosteric RegulationAnimalsDrug DesignIsoquinolinesMaleMice, Inbred C57BLMolecular StructurePyrazinesPyrrolesReceptors, N-Methyl-D-AspartateStructure-Activity RelationshipXenopus laevisIsoquinolinesNR2C NMDA receptorNR2D NMDA receptorPyrazinesPyrrolesReceptors, N-Methyl-D-Aspartate

Identifiers

PMID32538088
PMCPMC7961853
OpenAlexW3034606787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.