ArticleJournal of clinical laboratory analysis2020
Proteome profiling of gestational diabetes mellitus at 16-18 weeks revealed by LC-MS/MS.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Gestational diabetes mellitus - more than the eye can see - a warning sign for future maternal health with transgenerational impact.Frontiers in clinical diabetes and healthcare · 2025Review
- Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters.BMC pregnancy and childbirth · 2024Article
- Serum proteins differentially expressed in gestational diabetes mellitus assessed using isobaric tag for relative and absolute quantitation proteomics.World journal of clinical cases · 2024Article
- Postpartum defects in inflammatory response after gestational diabetes precede progression to type 2 diabetes: a nested case-control study within the SWIFT study.Metabolism: clinical and experimental · 2023Article
- Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds.Antioxidants (Basel, Switzerland) · 2023Review
- Role of Oxidative Stress and Inflammation in Gestational Diabetes Mellitus.Antioxidants (Basel, Switzerland) · 2023Review
- Serum Proteomic Signatures in Umbilical Cord Blood of Preterm Neonates Delivered by Women with Gestational Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Proteomics Studies in Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Article
- Proteome profiling of gestational diabetes mellitus at 16-18 weeks revealed by LC-MS/MS.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe practices used to diagnose gestational diabetes mellitus (GDM) could only be carried out around the time of detectable symptoms, and predictive capacity is little.
methodsLC-MS/MS was conducted to explore overview proteomics for GDM complicated pregnant woman at 16-18 gestation weeks, while normal pregnant for control. Enzyme-linked immunosorbent assay was further applied in an independent cohort of 15 GDM cases and 15 controls for verification.
resultsThe results indicated that 24 protein expression levels were significantly changed in GDM group samples, and inflammation, oxidative stress, insulin resistance, blood coagulation, and lipid homeostasis were associated with GDM. The abnormal expression of CRP and IGFBP2 was verified in the first-trimester maternal plasma in women who subsequently developed GDM.
conclusionsThis study not only identified 24 potential predictive biomarkers for GDM also provided a global overview of protein rearrangements induced by GDM.
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