Evidence map›Paper›PMID 32537662›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2020

Impaired cardiac function is associated with mortality in patients with acute COVID-19 infection.

Dominik Rath, Álvaro Petersen-Uribe, Alban Avdiu, Katja Witzel, Philippa Jaeger, Monika Zdanyte, David Heinzmann, Elli Tavlaki, Karin Müller, Meinrad Paul Gawaz

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04628195 (Cardiac Performance in Mechanically Ventilated Patients With Severe Pneumonia by SARS-CoV-2), which is not on this map. Cited by 82 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04628195 completednot on this map

Cardiac Performance in Mechanically Ventilated Patients With Severe Pneumonia by SARS-CoV-2: Echo-COVID Study

TypeobservationalSponsorPontificia Universidad Catolica de ChileRan2020 to 2020Enrolled100ConditionsCovid19, Acute Cor Pulmonale, Cardiac Failure
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 16 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Echocardiographic assessment of the right ventricle in COVID-19: a systematic review.The international journal of cardiovascular imaging · 2021
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Article
  18. Prospective electrocardiographic and cardiovascular magnetic resonance alterations in the UK Biobank coronavirus disease 2019 repeat imaging study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Article
  19. Review
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dominik RathDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
Álvaro Petersen-UribeDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
Alban AvdiuDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
Katja WitzelDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
Philippa JaegerDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
Monika ZdanyteDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
David HeinzmannDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
Elli TavlakiDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
Karin MüllerDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany.
Meinrad Paul GawazDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls Universität Tübingen, Otfried-Müller Str.10, 72076, Tübingen, Germany. meinrad.gawaz@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0003-1124-9592

Funding

Deutsche Forschungsgemeinschaft 374031971
6 · The paper itself

Abstract

backgroundCOVID-19 infection may cause severe respiratory distress and is associated with increased morbidity and mortality. Impaired cardiac function and/or pre-existing cardiovascular disease may be associated with poor prognosis. In the present study, we report a comprehensive cardiovascular characterization in the first consecutive collective of patients that was admitted and treated at the University Hospital of Tübingen, Germany.

methods123 consecutive patients with COVID-19 were included. Routine blood sampling, transthoracic echocardiography and electrocardiography were performed at hospital admission.

resultsWe found that impaired left-ventricular and right-ventricular function as well as tricuspid regurgitation > grade 1 were significantly associated with higher mortality. Furthermore, elevated levels of myocardial distress markers (troponin-I and NT pro-BNP) were associated with poor prognosis in this patient collective.

conclusionImpaired cardiac function is associated with poor prognosis in COVID-19 positive patients. Consequently, treatment of these patients should include careful guideline-conform cardiovascular evaluation and treatment. Thus, formation of a competent Cardio-COVID-19 team may represent a major clinical measure to optimize therapy of cardiovascular patients during this pandemic.

Indexed as

Ventricular Function, LeftVentricular Function, RightAgedAged, 80 and overCOVID-19FemaleGermanyHospitalizationHospital MortalityHumansMaleMiddle AgedPrognosisProspective StudiesRisk AssessmentRisk FactorsCardiac functionCardiovascular diseaseCOVID-19Heart failurePrognosis

Identifiers

PMID32537662
PMCPMC7293880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.