ArticleCerebral cortex (New York, N.Y. : 1991)2020
Brain Wiring and Supragranular-Enriched Genes Linked to Protracted Human Frontal Cortex Development.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Protocol for diffusion magnetic resonance imaging and tractography in ex vivo mouse models.STAR protocols · 2026Article
- From Circuits to Lifespan: Translating Mouse and Human Timelines with Neuroimaging-Based Tractography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- From circuits to lifespan: translating mouse and human timelines with neuroimaging based tractography.bioRxiv : the preprint server for biology · 2024Article
- Cerebellar structural, astrocytic, and neuronal abnormalities in the SMNΔ7 mouse model of spinal muscular atrophy.Brain pathology (Zurich, Switzerland) · 2023Article
- Mapping Human Brain Pathways: Challenges and Opportunities in the Integration of Scales.Brain, behavior and evolution · 2023Review
- Tracing Modification to Cortical Circuits in Human and Nonhuman Primates from High-Resolution Tractography, Transcription, and Temporal Dimensions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Self-tuition as an essential design feature of the brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- A natural cortical axis connecting the outside and inside of the human brain.Network neuroscience (Cambridge, Mass.) · 2022Article
- Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions.International journal of molecular sciences · 2021Review
- Cutting across structural and transcriptomic scales translates time across the lifespan in humans and chimpanzees.Proceedings. Biological sciences · 2021Article
- Closing the gap from transcription to the structural connectome enhances the study of connections in the human brain.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Differential timing of a conserved transcriptional network underlies divergent cortical projection routes across mammalian brain evolution.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The human frontal cortex is unusually large compared with many other species. The expansion of the human frontal cortex is accompanied by both connectivity and transcriptional changes. Yet, the developmental origins generating variation in frontal cortex circuitry across species remain unresolved. Nineteen genes that encode filaments, synapse, and voltage-gated channels are especially enriched in the supragranular layers of the human cerebral cortex, which suggests enhanced corticocortical projections emerging from layer III. We identify species differences in connections with the use of diffusion MR tractography as well as gene expression in adulthood and in development to identify developmental mechanisms generating variation in frontal cortical circuitry. We demonstrate that increased expression of supragranular-enriched genes in frontal cortex layer III is concomitant with an expansion in corticocortical pathways projecting within the frontal cortex in humans relative to mice. We also demonstrate that the growth of the frontal cortex white matter and transcriptional profiles of supragranular-enriched genes are protracted in humans relative to mice. The expansion of projections emerging from the human frontal cortex arises by extending frontal cortical circuitry development. Integrating gene expression with neuroimaging level phenotypes is an effective strategy to assess deviations in developmental programs leading to species differences in connections.
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