Evidence map›Paper›PMID 32537565›Full record

ArticleCardiovascular endocrinology & metabolism2020

Associations of adiponectin and leptin with brain natriuretic peptide in African Americans: the Jackson Heart Study.

Steven R Horbal, Michael E Hall, Paul C Dinh, Abbas Smiley, Solomon K Musani, Jiankang Liu, Herman A Taylor, Ervin R Fox, Aurelian Bidulescu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular endocrinology & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Steven R HorbalIndiana University School of Public Health, Bloomington, Indiana.
Michael E HallUniversity of Mississippi Medical Center, Jackson, Mississippi.
Paul C DinhIndiana University School of Public Health, Bloomington, Indiana.
Abbas SmileyIndiana University School of Public Health, Bloomington, Indiana.
Solomon K MusaniUniversity of Mississippi Medical Center, Jackson, Mississippi.
Jiankang LiuBrigham and Women's Hospital, Boston, Massachusetts.
Herman A TaylorMorehouse School of Medicine, Atlanta, Georgia, USA.
Ervin R FoxUniversity of Mississippi Medical Center, Jackson, Mississippi.
Aurelian BidulescuIndiana University School of Public Health, Bloomington, Indiana.
Indiana University Bloomington · USUniversity of Mississippi Medical Center · USBrigham and Women's Hospital · USMorehouse School of Medicine · US

Funding

Renal Sinus Fat, Hypertension, and Altered Kidney FunctionK08DK099415 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, MICHAEL EDWARD · 2015 to 2019
$791k
NIDDK NIH HHS K08 DK099415
6 · The paper itself

Abstract

Brain natriuretic peptide (BNP) is elevated in decompensated systolic and diastolic heart failure. The plasma levels of adipokines, such as adiponectin and leptin, may provide evidence for mechanistic differences in BNP concentrations. African-American-specific associations are limited in the literature. The objective of this study was to evaluate the associations of adiponectin and leptin with BNP among African Americans.

methodsLinear and logistic regressions were used to test the associations between adiponectin, leptin, and plasma BNP in 3738 participants of the Jackson Heart Study (JHS), a single-site prospective cohort study of African Americans in Jackson, Mississippi.

resultsA direct relationship of adiponectin was observed in multiple multivariate-adjusted linear models: in men (

conclusionsDifferent linear associations of adiponectin and leptin with BNP were observed. Odds of elevated adiponectin were observed with elevated BNP in multivariate-adjusted models. This paradoxical relationship of adiponectin and plasma BNP is possibly explained through adiponectin resistance.

Indexed as

adiponectinAfrican Americansbrain natriuretic peptideleptin

Identifiers

PMID32537565
PMCPMC7228776
OpenAlexW3022284023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.