Evidence map›Paper›PMID 32537530›Full record

ReviewNetwork neuroscience (Cambridge, Mass.)2020

Decoding the circuitry of consciousness: From local microcircuits to brain-scale networks.

Julien Modolo, Mahmoud Hassan, Fabrice Wendling, Pascal Benquet

Open access · goldAbstract readReview
In one paragraph

Review in Network neuroscience (Cambridge, Mass.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 citations in OpenAlex.

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  19. Segregated brain state during hypnosis.Neuroscience of consciousness · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Julien ModoloUniversity of Rennes, INSERM, LTSI-U1099, Rennes, France.ORCID https://orcid.org/0000-0002-5973-7571
Mahmoud HassanUniversity of Rennes, INSERM, LTSI-U1099, Rennes, France.ORCID https://orcid.org/0000-0003-0307-5086
Fabrice WendlingUniversity of Rennes, INSERM, LTSI-U1099, Rennes, France.ORCID https://orcid.org/0000-0003-2428-9665
Pascal BenquetUniversity of Rennes, INSERM, LTSI-U1099, Rennes, France.ORCID https://orcid.org/0000-0003-0217-5886
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying the physiological processes underlying the emergence and maintenance of consciousness is one of the most fundamental problems of neuroscience, with implications ranging from fundamental neuroscience to the treatment of patients with disorders of consciousness (DOCs). One major challenge is to understand how cortical circuits at drastically different spatial scales, from local networks to brain-scale networks, operate in concert to enable consciousness, and how those processes are impaired in DOC patients. In this review, we attempt to relate available neurophysiological and clinical data with existing theoretical models of consciousness, while linking the micro- and macrocircuit levels. First, we address the relationships between awareness and wakefulness on the one hand, and cortico-cortical and thalamo-cortical connectivity on the other hand. Second, we discuss the role of three main types of GABAergic interneurons in specific circuits responsible for the dynamical reorganization of functional networks. Third, we explore advances in the functional role of nested oscillations for neural synchronization and communication, emphasizing the importance of the balance between local (high-frequency) and distant (low-frequency) activity for efficient information processing. The clinical implications of these theoretical considerations are presented. We propose that such cellular-scale mechanisms could extend current theories of consciousness.

Indexed as

Communication through coherenceDisorders of consciousnessElectroencephalographyFunctional connectivityGating by inhibitionMicro-circuitry

Identifiers

PMID32537530
PMCPMC7286300
OpenAlexW2966694333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.