Evidence map›Paper›PMID 32537485›Full record

ArticleScience advances2020

A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and

Xiaoliang Wang, Liquan Cai, Jeffrey X Xie, Xiaoyu Cui, Jue Zhang, Jiayan Wang, Yiliang Chen, Isabel Larre, Joseph I Shapiro, Sandrine V Pierre and 3 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Role of Na/K-ATPase α1 caveolin-binding motif in adipogenesis.American journal of physiology. Cell physiology · 2024
    Article
  3. Review
  4. Article
  5. COX2-ATP Synthase Regulates Spine Follicle Size in Hedgehogs.International journal of biological sciences · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Xiaoliang WangMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.ORCID 0000-0003-2666-1133
Liquan CaiMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.
Jeffrey X XieUniversity of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Xiaoyu CuiMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.
Jue ZhangMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.
Jiayan WangMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.
Yiliang ChenBlood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-9786-8305
Isabel LarreMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.ORCID 0000-0003-0768-3556
Joseph I ShapiroJoan C. Edwards School of Medicine at Marshall University, Huntington, WV, USA.
Sandrine V PierreMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.
Dianqing WuDepartment of Pharmacology and Vascular Biology and Therapeutics, Yale School of Medicine, New Haven, CT, USA.
Guo-Zhang ZhuMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.ORCID 0000-0002-1573-618X
Zijian XieMarshall Institute for Interdisciplinary Research (MIIR) at Marshall University, Huntington, WV, USA.ORCID 0000-0001-5476-336X
Marshall University · USUniversity of Toledo · USVersiti Blood Center of Wisconsin · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
DKK2 regulates NK activation and tumor immunityR01CA214703 · NCI · YALE UNIVERSITY · PI WU, DIANQING · 2018 to 2022
$2.5M
Mechanisms for Wnt SignalingR01GM112182 · NIGMS · YALE UNIVERSITY · PI HA, YA, WU, DIANQING · 2014 to 2018
$1.5M
The Na/K-ATPase receptor function as a novel therapeutic target in myocardial infarctionR15HL145666 · NHLBI · MARSHALL UNIVERSITY · PI PIERRE, SANDRINE V · 2019 to 2019
$444k
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA214703NHLBI NIH HHS R15 HL145666NIGMS NIH HHS R01 GM112182
6 · The paper itself

Abstract

Several signaling events have been recognized as essential for regulating cell lineage specification and organogenesis in animals. We find that the gain of an amino-terminal caveolin binding motif (CBM) in the α subunit of the Na/K-adenosine triphosphatase (ATPase) (NKA) is required for the early stages of organogenesis in both mice and

Indexed as

Caenorhabditis elegansSodium-Potassium-Exchanging ATPaseAnimalsCaveolin 1Cell DifferentiationMammalsMiceOrganogenesisCaveolin 1Sodium-Potassium-Exchanging ATPase

Identifiers

PMID32537485
PMCPMC7253156
OpenAlexW3029842508

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.