ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020
Immune Modulation by Design: Using Topography to Control Human Monocyte Attachment and Macrophage Differentiation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed.
- AI for bioactive materials: From material design to biological applications.Bioactive materials · 2026Review
- Molecular Design of Biobased, Printable Monomers for Two-Photon Polymerization.Macromolecular rapid communications · 2026Article
- Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices.Bioactive materials · 2026Article
- Light-Responsive Surface Topographies Modulate Macrophage Immune Responses Through Dynamic Mechanical Cues.Macromolecular bioscience · 2026Article
- Osteoimmunology uncovered: How macrophages and biomaterials revolutionize bone healing.Materials today. Bio · 2026Review
- Diminished fibrotic encapsulation and comparable physicochemical properties of poly (styrene-Frontiers in bioengineering and biotechnology · 2026Article
- Macrophage-derived exosomal miR-466i-5p and miR-365-2-5p stimulated by BMP-2 promote osteogenesis.Journal of orthopaedic surgery and research · 2025Article
- Peptide-Functionalized Nanopillared Surfaces with Tunable Antimicrobial and Immunomodulatory Properties.ACS omega · 2025Article
- Immunomodulatory bioadhesive technologies.Biomaterials · 2025Review
- High-Throughput Analysis of Protein Adsorption to a Large Library of Polymers Using Liquid Extraction Surface Analysis-Tandem Mass Spectrometry (LESA-MS/MS).Analytical chemistry · 2025Article
- Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.Nature communications · 2025Article
- Modulation of Biomaterial-Associated Fibrosis by Means of Combined Physicochemical Material Properties.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Free and encapsulated stem cells for skin regeneration.BioImpacts : BI · 2025Review
- Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation.Research (Washington, D.C.) · 2025Article
- Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The influence of biophysical niche on tumor-associated macrophages in liver cancer.Hepatology communications · 2024Review
- Inflammatory or Reparative? Tuning Macrophage Polarization Using Anodized Anisotropic Nanoporous Titanium Implant Surfaces.Small science · 2024Article
- Electrospun Fiber Surface Roughness Modulates Human Monocyte-Derived Macrophage Phenotype.bioRxiv : the preprint server for biology · 2024Article
- Advances and applications of biomimetic biomaterials for endogenous skin regeneration.Bioactive materials · 2024Review
- The regulatory effect of TiOBMC oral health · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages play a central role in orchestrating immune responses to foreign materials, which are often responsible for the failure of implanted medical devices. Material topography is known to influence macrophage attachment and phenotype, providing opportunities for the rational design of "immune-instructive" topographies to modulate macrophage function and thus foreign body responses to biomaterials. However, no generalizable understanding of the inter-relationship between topography and cell response exists. A high throughput screening approach is therefore utilized to investigate the relationship between topography and human monocyte-derived macrophage attachment and phenotype, using a diverse library of 2176 micropatterns generated by an algorithm. This reveals that micropillars 5-10 µm in diameter play a dominant role in driving macrophage attachment compared to the many other topographies screened, an observation that aligns with studies of the interaction of macrophages with particles. Combining the pillar size with the micropillar density is found to be key in modulation of cell phenotype from pro to anti-inflammatory states. Machine learning is used to successfully build a model that correlates cell attachment and phenotype with a selection of descriptors, illustrating that materials can potentially be designed to modulate inflammatory responses for future applications in the fight against foreign body rejection of medical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.