Evidence map›Paper›PMID 32537071›Full record

ArticleThe Pan African medical journal2020

Human papillomavirus genotype profiles and cytological grades interlinkages in coinfection with HIV.

Lucy Wanja Karani, Stanslaus Musyoki, Robert Orina, Anthony Kebira Nyamache, Christopher Khayeka-Wandabwa, Benuel Nyagaka

Open access · goldAbstract read
In one paragraph

Article in The Pan African medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Lucy Wanja KaraniSchool of Health Science, Kisii University, Kisii, Kenya.
Stanslaus MusyokiSchool of Health Science, Kisii University, Kisii, Kenya.
Robert OrinaSchool of Health Science, Kisii University, Kisii, Kenya.
Anthony Kebira NyamacheDepartment of Microbiology, Kenyatta University, Nairobi, Kenya.
Christopher Khayeka-WandabwaSchool of Pharmaceutical Science and Technology (SPST), Health Science Platform, Tianjin University, Tianjin 300072, China.
Benuel NyagakaSchool of Health Science, Kisii University, Kisii, Kenya.
Kisii University · KEKenyatta University · KETianjin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe study aimed to examine and characterize human papilloma virus (HPV) cytological grade trends and genotypes among HPV/HIV co-infected/cases and HPV monoinfected/control women attending Kisii Teaching and Referral Hospital, Kenya.

methodsHIV positive co-infected with HPV (HPV/HIV) and HIV negative women monoinfected with HPV profiled as co-infected/cases and monoinfected/control arms respectively were enrolled. HPV subtypes were assayed by Xpert

resultsLow grade intraepithelial lesion (LSIL) was the most predominant cytological grade across cases and controls with a prevalence of 32 (38.1%) while high grade squamous intraepithelial lesion (HSIL) was highest among HPV/HIV co-infected with a prevalence of 23 (27.38%). Among the monoinfected (controls) the predominant lesion was low grade intraepithelial lesions (LSIL) with a prevalence of 23 (27.38%). HPV type 16 had the highest prevalence 26 (30.8%) among the VIA positive women in the overall study participants followed by combinations of HPV types (16, 18/45) at 19 (22.6%).

conclusionHigh risk HPV types 16 and 18/45 were the most predominant in the established cytological grades and among the co-infected women. Routine screening using both cytological and HPV testing should be embraced and/or reinforced as early screening and preventive strategies in the covered geographical region population. Provision of the currently available vaccines to these women at an early age would provide effective protection since the HPV type profiles in this population are covered by such vaccines.

Indexed as

Mass ScreeningAdolescentAdultAlphapapillomavirusCase-Control StudiesCoinfectionFemaleGenotypeHIV InfectionsHumansKenyaMiddle AgedPapillomavirus InfectionsSquamous Intraepithelial Lesions of the CervixUterine Cervical DysplasiaUterine Cervical Neoplasmscervical carcinomaco-infectiongenotypeHuman immunodeficiency virushuman papillomaviruspathologyvaccine

Identifiers

PMID32537071
PMCPMC7250203
OpenAlexW3011605500

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.