Evidence map›Paper›PMID 32536902›Full record

ArticleFrontiers in neurology2020

Cortical Damage Associated With Cognitive and Motor Impairment in Hereditary Spastic Paraplegia: Evidence of a Novel

Jian-Zhong Lin, Hong-Hua Zheng, Qi-Lin Ma, Chen Wang, Li-Ping Fan, Han-Ming Wu, Dan-Ni Wang, Jia-Xing Zhang, Yi-Hong Zhan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  6. Article
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  9. A Novel SPAST Mutation Results in Spastin Accumulation and Defects in Microtubule Dynamics.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jian-Zhong LinMagnetic Resonance Center, The Affiliated Zhongshan Hospital of Xiamen University, Xiamen, China.
Hong-Hua ZhengFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China.
Qi-Lin MaDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Chen WangDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Li-Ping FanDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Han-Ming WuDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Dan-Ni WangDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Jia-Xing ZhangInstitute of Brain Diseases and Cognition, School of Medicine, Xiamen University, Xiamen, China.
Yi-Hong ZhanDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
First Affiliated Hospital of Xiamen University · CNXiamen University · CNZhongshan Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To determine the cortical mechanism that underlies the cognitive impairment and motor disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family were examined using clinical evaluation, cognitive screening, and genetic testing. Controls were matched healthy subjects. White-matter fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD; tract-based spatial statistics), cortical thickness (FreeSurfer), and subcortical gray matter (FIRST) based on T1-weighted MRI and diffusion tensor imaging were analyzed. A novel mutation in the

Indexed as

braingray-matter changesMRISPAST gene mutationSPG4-hereditary spastic paraplegia

Identifiers

PMID32536902
PMCPMC7267220
OpenAlexW3029855207

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.