ArticleNeurologia medico-chirurgica2020
Hemodynamic and Histopathological Changes in the Early Phase of the Development of an Intracranial Aneurysm.
Article in Neurologia medico-chirurgica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Knowledge domain and emerging trends in the rupture risk of intracranial aneurysms research from 2004 to 2023.World journal of clinical cases · 2024Article
- Nesfatin-1 inhibits cerebral aneurysms by activating Nrf2 and inhibiting NF-κB signaling.CNS neuroscience & therapeutics · 2024Article
- Time-of-flight and black-blood MRI to study intracranial arteries in rats.European radiology experimental · 2024Article
- High wall shear stress-dependent podosome formation in a novel murine model of intracranial aneurysm.Frontiers in stroke · 2024Article
- Early vascular embolization improves neurological function in patients with intracranial aneurysm.American journal of translational research · 2024Article
- Screening of immune-related biological markers for aneurysmal subarachnoid hemorrhage based on machine learning approaches.Biochemistry and biophysics reports · 2023Article
- Article
- Computational Fluid Dynamics Analysis Features in Aneurysm Development in Rats.Neurologia medico-chirurgica · 2023Article
- Effects of helical centerline stent vs. straight stent placement on blood flow velocity.Frontiers in medical technology · 2023Article
- Global tendencies and frontier topics in hemodynamics research of intracranial aneurysms: a bibliometric analysis from 1999 to 2022.Frontiers in physiology · 2023Article
- Association of bleb formation with peri-aneurysmal contact in unruptured intracranial aneurysms.Scientific reports · 2022Article
- Direct visualization of interstitial flow distribution in aortic walls.Scientific reports · 2022Article
- Intracranial Aneurysms Induced byFrontiers in neurology · 2022Article
- DNA methylation and mRNA expression of glutathione S-transferase alpha 4 are associated with intracranial aneurysms in a gender-dependent manner.Frontiers in genetics · 2022Article
- Flow Diversion for the Management of Ruptured Intracranial Arterial Infudibular Dilatation: Proof of Principle and Therapeutic Protocol.Frontiers in neurology · 2022Article
- The biology of bone morphogenetic protein signaling pathway in cerebrovascular system.Chinese neurosurgical journal · 2021Review
- Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review.Frontiers in cardiovascular medicine · 2021Review
- Trauma may affect vasa vasorum to promote thrombosis and enlargement of intracranial aneurysms: A case report.Surgical neurology international · 2021Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemodynamic stress and chronic inflammation are closely associated with the pathogenesis of intracranial aneurysms (IAs). However, the hemodynamic and biological mechanisms triggering IA formation remain to be elucidated. To clarify them, computational fluid dynamics (CFD) and histopathological analyses in the early phase of IA development using an experimentally induced IA model in rats were conducted. Histological changes in the early phase of IA development were observed under a scanning electron microscope (SEM) and a transmission electron microscope (TEM). Using data from 7-T magnetic resonance angiography (7T-MRA), CFD analyses were performed to determine wall shear stress (WSS) and wall pressure (WP) at the prospective site of IA. A bump-like protrusion named an "intimal pad" was located in the anterior cerebral artery (ACA) immediately distal to the apex of the bifurcation. TEM showed the degeneration of the internal elastic lamina (IEL) and longitudinally elongated smooth muscle cells (SMCs) that switched from the contractile to the proliferative phenotype and penetrated between two divided layers of the degenerated IEL in the prospective site of the IA. However, no inflammatory cells were observed. CFD analyses showed no particular pattern of WSS and WP at the prospective IA site. IEL degeneration and the phenotypic change and longitudinal elongation of SMCs were identified as the early events in IA development. CFD analyses and TEM data suggest that these biological events may be derived from increased circumferential wall stress due to increased blood pressure and increased longitudinal wall strain due to the existence of the intimal pad.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.