Evidence map›Paper›PMID 32536203›Full record

ArticleCirculation. Arrhythmia and electrophysiology2020

Single-Molecule Localization of the Cardiac Voltage-Gated Sodium Channel Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains.

Sarah H Vermij, Jean-Sébastien Rougier, Esperanza Agulló-Pascual, Eli Rothenberg, Mario Delmar, Hugues Abriel

Open access · hybridAbstract read
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sarah H VermijInstitute of Biochemistry and Molecular Medicine, University of Bern, Switzerland (S.H.V., J.-S.R., H.A.).
Jean-Sébastien RougierInstitute of Biochemistry and Molecular Medicine, University of Bern, Switzerland (S.H.V., J.-S.R., H.A.).
Esperanza Agulló-PascualMicroscopy Core, Icahn School of Medicine at Mount Sinai, New York, NY (E.A.-P.).
Eli RothenbergDepartment of Biochemistry and Pharmacology (E.R.), New York University School of Medicine, NY.
Mario DelmarDepartment of Cardiology (M.D.), New York University School of Medicine, NY.
Hugues AbrielInstitute of Biochemistry and Molecular Medicine, University of Bern, Switzerland (S.H.V., J.-S.R., H.A.).
University of Bern · CHNew York University · USIcahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMutations in the gene encoding the cardiac voltage-gated sodium channel Na

methodsWe used novel single-molecule localization microscopy and computational modeling to define nanoscale features of Na

resultsWe show that Na

conclusionsNa

Indexed as

Ion Channel GatingSingle Molecule ImagingAnimalsCell MembraneComputer SimulationDystrophinMembrane PotentialsMice, Inbred mdxMice, TransgenicModels, CardiovascularMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelProtein TransportDystrophinNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mousecardiac arrhythmiascardiomyocytedystrophinelectrophysiologymembranesmicroscopysodium channel

Identifiers

PMID32536203
PMCPMC7368852
OpenAlexW3034808133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.