Evidence map›Paper›PMID 32536001›Full record

ReviewMolecular oncology2020

Image guidance in radiation therapy for better cure of cancer.

Vincent Grégoire, Matthias Guckenberger, Karin Haustermans, Jan J W Lagendijk, Cynthia Ménard, Richard Pötter, Ben J Slotman, Kari Tanderup, Daniela Thorwarth, Marcel van Herk and 1 more

Abstract readReview
In one paragraph

Review in Molecular oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Economic Evaluations of Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  2. Article
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  7. Review
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  13. Non-Invasive Imaging in Post-Radiotherapy Monitoring of Non-Melanoma Skin Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
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  15. Article
  16. Article
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  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vincent GrégoireDepartment of Radiation Oncology, Léon Bérard Cancer Center, Lyon, France.
Matthias GuckenbergerDepartment for Radiation Oncology, University Hospital Zurich, University of Zurich, Switzerland.
Karin HaustermansDepartment of Radiation Oncology, Leuven Cancer Institute, University Hospital Gasthuisberg, Leuven, Belgium.
Jan J W LagendijkDepartment of Radiotherapy, University Medical Center Utrecht, The Netherlands.
Cynthia MénardCentre Hospitalier de l'Université de Montréal, Canada.
Richard PötterDepartment of Radiation Oncology, Medical University, General Hospital of Vienna, Austria.
Ben J SlotmanDepartment of Radiation Oncology, Amsterdam University Medical Centers, The Netherlands.
Kari TanderupDepartment of Oncology, Aarhus University Hospital, Denmark.
Daniela ThorwarthSection for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Germany.
Marcel van HerkDepartment of Biomedical Engineering and Physics, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, The Netherlands.
Daniel ZipsDepartment of Radiation Oncology, University of Tübingen, Germany.ORCID 0000-0001-5779-9675

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The key goal and main challenge of radiation therapy is the elimination of tumors without any concurring damages of the surrounding healthy tissues and organs. Radiation doses required to achieve sufficient cancer-cell kill exceed in most clinical situations the dose that can be tolerated by the healthy tissues, especially when large parts of the affected organ are irradiated. High-precision radiation oncology aims at optimizing tumor coverage, while sparing normal tissues. Medical imaging during the preparation phase, as well as in the treatment room for localization of the tumor and directing the beam, referred to as image-guided radiotherapy (IGRT), is the cornerstone of precision radiation oncology. Sophisticated high-resolution real-time IGRT using X-rays, computer tomography, magnetic resonance imaging, or ultrasound, enables delivery of high radiation doses to tumors without significant damage of healthy organs. IGRT is the most convincing success story of radiation oncology over the last decades, and it remains a major driving force of innovation, contributing to the development of personalized oncology, for example, through the use of real-time imaging biomarkers for individualized dose delivery.

Indexed as

Radiotherapy, Image-GuidedHumansMagnetic Resonance ImagingMolecular ImagingNeoplasmsRadiation OncologyTomography, X-Ray Computedadaptive radiotherapybrachytherapycone-beam CTimage guidancemolecular imagingMR-linacradiationstereotactic radiotherapy

Identifiers

PMID32536001
PMCPMC7332209

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.