Evidence map›Paper›PMID 32535988›Full record

ArticleCancer science2020

CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model.

Megumi Saito, Naoko Kagawa, Kazuhiro Okumura, Haruka Munakata, Eriko Isogai, Tatsuo Fukagawa, Yuichi Wakabayashi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Megumi SaitoDepartment of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, Chiba, Japan.
Naoko KagawaDepartment of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Japan.
Kazuhiro OkumuraDepartment of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, Chiba, Japan.
Haruka MunakataDepartment of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, Chiba, Japan.
Eriko IsogaiDepartment of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, Chiba, Japan.
Tatsuo FukagawaDepartment of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Japan.
Yuichi WakabayashiDepartment of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, Chiba, Japan.ORCID https://orcid.org/0000-0002-8861-2954
Chiba Cancer Center · JPNational Institute of Genetics · JP

Funding

Japan Society for the Promotion of Science 15H05972Japan Society for the Promotion of Science 23790435Japan Society for the Promotion of Science 25221106
6 · The paper itself

Abstract

CENP-50/U is a component of the CENP-O complex (CENP-O/P/Q/R/U) and localizes to the centromere throughout the cell cycle. Aberrant expression of CENP-50/U has been reported in many types of cancers. However, as Cenp-50/U-deficient mice die during early embryogenesis, its functions remain poorly understood in vivo. To investigate the role of Cenp-50/U in skin carcinogenesis, we generated Cenp-50/U conditional knockout (K14Cre

Indexed as

9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinogenesisCarcinogensCell Cycle ProteinsHumansMiceMice, KnockoutNeoplasms, ExperimentalPapillomaPhthalic AcidsSkinSkin Neoplasms9,10-Dimethyl-1,2-benzanthraceneCarcinogensCell Cycle ProteinsMLF1-IP protein, mousePhthalic Acidsterephthalic acidCENPmalignant conversionmouse modelspapillomatwo-stage skin carcinogenesis

Identifiers

PMID32535988
PMCPMC7419024
OpenAlexW3035669575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.