Evidence map›Paper›PMID 32535955›Full record

ReviewAllergy2020

A compendium answering 150 questions on COVID-19 and SARS-CoV-2.

Carmen Riggioni, Pasquale Comberiati, Mattia Giovannini, Ioana Agache, Mübeccel Akdis, Magna Alves-Correia, Josep M Antó, Alessandra Arcolaci, Ahmet Kursat Azkur, Dilek Azkur and 32 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Allergy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Assessing the Burden of Thromboembolic Complications in Outpatient COVID-19 Cases: A Focused Study on Patients Followed in Primary Care.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. COVID-19 Biogenesis and Intracellular Transport.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Chronic Rhinosinusitis and COVID-19.The journal of allergy and clinical immunology. In practice · 2022
    Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 23 countries.

Carmen RiggioniPediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0002-8745-0228
Pasquale ComberiatiSection of Pediatrics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0001-5209-9733
Mattia GiovanniniAllergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.ORCID 0000-0001-9568-6882
Ioana AgacheFaculty of Medicine, Transylvania University, Brasov, Romania.ORCID 0000-0001-7994-364X
Mübeccel AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0003-0554-9943
Magna Alves-CorreiaAllergy Unit, CUF Porto Hospital & Institute, Oporto, Portugal.ORCID 0000-0002-7676-5558
Josep M AntóISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.ORCID 0000-0002-4736-8529
Alessandra ArcolaciAllergy Unit & Asthma Center, Borgo Roma Hospital, University of Verona and General Hospital, Verona, Italy.
Ahmet Kursat AzkurDepartment of Virology, Faculty of Veterinary Medicine, University of Kirikkale, Kirikkale, Turkey.ORCID 0000-0002-5597-8917
Dilek AzkurDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of Kirikkale, Kirikkale, Turkey.ORCID 0000-0002-4396-9087
Burcin BekenDepartment of Pediatric Allergy and Immunology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.ORCID 0000-0001-7677-7690
Cristina BoccabellaDepartment of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario "A Gemelli" - IRCCS, University of the Sacred Heart, Rome, Italy.ORCID 0000-0003-1942-8886
Jean BousquetCharité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Heimo BreitenederInstitute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2022-8689
Daniela CarvalhoPublic Health Research Center, NOVA University of Lisbon, Lisboa, Portugal.ORCID 0000-0002-0432-3339
Leticia De Las VecillasDepartment of Allergy, Marqués de Valdecilla University Hospital-IDIVAL, Santander, Spain.ORCID 0000-0003-4969-5678
Zuzana DiamantDepartment of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden.ORCID 0000-0003-0133-0100
Ibon Eguiluz-GraciaAllergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, RETICS ARADyAL, BIONAND, Malaga, Spain.ORCID 0000-0002-3774-931X
Thomas EiweggerDivision of Immunology and Allergy, Food Allergy and Anaphylaxis Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-2914-7829
Stefanie EyerichZAUM - Center of Allergy and Environment, Technical University and Helmholtz Center Munich, Munich, Germany.
Wytske FokkensDepartment of Otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0003-4852-229X
Ya-Dong GaoDepartment of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.ORCID 0000-0003-1251-7608
Farah HannachiImmuno-Allergology Unit, Hospital Centre of Luxembourg, Luxembourg, Luxembourg.
Sebastian L JohnstonNational Heart and Lung Institute, Imperial College London, London, UK.
Marek JutelDepartment of Clinical Immunology, University of Wroclaw, Wroclaw, Poland.
Aspasia KaraveliaENT Department, General Hospital of Chania, Greece, Greece.
Ludger KlimekCenter for Rhinology and Allergology, Wiesbaden, Germany.
Beatriz MoyaAllergy Unit, Hospital Universitario 12 de Octubre, Madrid, Spain.
Kari C NadeauDivision of Pulmonary and Critical Care Medicine, Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2146-2955
Robyn O'HehirDepartment of Immunology and Pathology, Monash University, Melbourne, Vic., Australia.
Liam O'MahonyDepartment of Medicine and School of Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0003-4705-3583
Oliver PfaarDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.ORCID 0000-0003-4374-9639
Marek SanakDepartment of Medicine, Jagiellonian University Medical College, Krakow, Poland.ORCID 0000-0001-7635-8103
Jürgen SchwarzeCentre for Inflammation Research, Child Life and Health, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-6899-748X
Milena SokolowskaSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0001-9710-6685
María J TorresAllergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, RETICS ARADyAL, BIONAND, Malaga, Spain.ORCID 0000-0001-5228-471X
Willem van de VeenSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0001-9951-6688
Menno C van ZelmDepartment of Immunology and Pathology, Monash University, Melbourne, Vic., Australia.ORCID 0000-0003-4161-1919
De Yun WangDepartment of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-0909-2963
Luo ZhangDepartment of Otolaryngology Head and Neck Surgery and Department of Allergy, Beijing Tongren Hospital, Beijing, China.ORCID 0000-0002-0910-9884
Rodrigo Jiménez-SaizDepartment of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.ORCID 0000-0002-0606-3251
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0001-8020-019X
University of Zurich · CHHospital Regional Universitario de Málaga · ESKırıkkale University · TRThe Alfred Hospital · AUAgostino Gemelli University Polyclinic · ITAmsterdam University Medical Centers · NLBeijing Tongren Hospital · CNCentre for Inflammation Research · GBCentre Hospitalier de Luxembourg · LUChania General Hospital ”St. George” · GRHelmholtz Zentrum München · DEHospital Sant Joan de Déu Barcelona · ESHospital Universitario 12 De Octubre · ESHumboldt-Universität zu Berlin · DEImperial College London · GBİstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi · TRJagiellonian University · PLMarqués de Valdecilla University Hospital · ESMedical University of Vienna · ATMeyer Children's Hospital · IT

Funding

Consejo Superior de Investigaciones Científicas IJCI-2016-27619Instituto de Salud Carlos III JR19/0029NHMRC Senior Research Fellowship GNT1117687
6 · The paper itself

Abstract

In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19HumansHypersensitivityPandemicsPneumonia, ViralSARS-CoV-2allergycoronavirus disease 2019COVID-19SARS-CoV-2severe acute respiratory syndrome-related coronavirus 2

Identifiers

PMID32535955
PMCPMC7323196
OpenAlexW3034723589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.