Evidence map›Paper›PMID 32535856›Full record

ArticleAging clinical and experimental research2021

Morbidity, mortality, and quality assessment following open radical cystectomy in elderly patients with bladder cancer.

Tommaso Prayer Galetti, Matteo Soligo, Alessandro Morlacco, Valeria Lami, Alex Anh Ly Nguyen, Massimo Iafrate, Filiberto Zattoni

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In one paragraph

Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tommaso Prayer GalettiUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy. tommaso.prayer@aopd.veneto.it.ORCID http://orcid.org/0000-0002-5915-0439
Matteo SoligoUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Alessandro MorlaccoUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Valeria LamiUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Alex Anh Ly NguyenUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Massimo IafrateUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Filiberto ZattoniUrology Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOpen radical cystectomy (ORC) with pelvic lymph-node dissection (PLND) for bladder cancer (BCa) and urinary diversion is a morbid procedure, and advanced age has been associated with a higher incidence of Clavien-Dindo ≥ 3 complications.

aimTo investigate the association between chronological age, survival outcomes, incidence of perioperative complications, and quality parameters in patients undergoing ORC.

methodsWe reviewed 413 patients who underwent ORC and PLND at a single academic centre between December 2009 and June 2018 for cT2-T4N0M0 BCa. Complete clinical, demographic, and pathological data were collected in the preoperative, preoperative, and postoperative setting. Patients were categorized as ≥ 75 years or < 75 years and statistical analysis was performed accordingly. Besides descriptive statistics, Kaplan-Meier log-rank test was used. Cox regression univariate and multivariate analyses were used to assess any potential predictor of OS and CSS.

resultsThere were 285 (69%) patients < 75 years and 128 (31%) patients ≥ 75 years old. There was no significant difference between the two age groups neither in terms of distribution of pathological stage nor in terms of overall incidence of postoperative complications. Chronological age was not significantly associated with survival outcomes on multivariate analysis. Finally, the comorbidity index was the only significant risk factor for the incidence of any complications (OR = 0.83, p = 0.002) at multivariate binary logistic regression.

conclusionOpen radical cystectomy (ORC) is a feasible and safe procedure in patients with high-risk non-metastatic bladder cancer. Uro-oncologists should consider evaluating elderly patients for surgery according to a thorough geriatric assessment despite chronological age.

Indexed as

Robotic Surgical ProceduresUrinary Bladder NeoplasmsAgedCystectomyHumansLymph Node ExcisionMorbidityPostoperative ComplicationsRetrospective StudiesTreatment OutcomeBladder cancerCharlsonComplicationsCystectomyElderly

Identifiers

PMID32535856
OpenAlexW3035054336

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.