Evidence map›Paper›PMID 32535655›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Generalization of deep learning models for ultra-low-count amyloid PET/MRI using transfer learning.

Kevin T Chen, Matti Schürer, Jiahong Ouyang, Mary Ellen I Koran, Guido Davidzon, Elizabeth Mormino, Solveig Tiepolt, Karl-Titus Hoffmann, Osama Sabri, Greg Zaharchuk and 1 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
  4. Review
  5. Data-efficient generalization of AI transformers for noise reduction in ultra-fast lung PET scans.European journal of nuclear medicine and molecular imaging · 2025
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  14. PET image denoising based on denoising diffusion probabilistic model.European journal of nuclear medicine and molecular imaging · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kevin T ChenDepartment of Radiology, Stanford University, Stanford, CA, United States. ktchen@stanford.edu.ORCID 0000-0001-8556-5307
Matti SchürerDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Jiahong OuyangDepartment of Radiology, Stanford University, Stanford, CA, United States.
Mary Ellen I KoranDepartment of Radiology, Stanford University, Stanford, CA, United States.
Guido DavidzonDepartment of Radiology, Stanford University, Stanford, CA, United States.
Elizabeth MorminoDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Solveig TiepoltDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Karl-Titus HoffmannDepartment of Neuroradiology, University Hospital Leipzig, Leipzig, Germany.
Osama SabriDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Greg ZaharchukDepartment of Radiology, Stanford University, Stanford, CA, United States.
Henryk BarthelDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.

Funding

Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0M
Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
Working Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2015 to 2019
$7.9M
NIA NIH HHS P30 AG066515NIA NIH HHS P50 AG047366NIBIB NIH HHS P41 EB015891NIH HHS P41-EB015891NIH HHS P50-AG047366
6 · The paper itself

Abstract

purposeWe aimed to evaluate the performance of deep learning-based generalization of ultra-low-count amyloid PET/MRI enhancement when applied to studies acquired with different scanning hardware and protocols.

methodsEighty simultaneous [

resultsAll network-synthesized images had reduced noise than their ultra-low-count reconstructions. Quantitatively, image metrics improved the most using method B, where SUVRs had the least variability from the ground-truth and the highest effect size to differentiate between positive and negative images. Method A images had lower accuracy and image quality than other methods; images synthesized from methods B-D scored similarly or better than the ground-truth images.

conclusionsDeep learning can successfully produce diagnostic amyloid PET images from short frame reconstructions. Data bias should be considered when applying pre-trained deep ultra-low-count amyloid PET/MRI networks for generalization.

Indexed as

Deep LearningAmyloidFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingPositron-Emission TomographyTomography, X-Ray ComputedAmyloidAmyloid PETLow-count imagingPET/MRITransfer learning

Identifiers

PMID32535655
PMCPMC7680289

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.