Evidence map›Paper›PMID 32535617›Full record

ArticleOncogene2020

Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma.

Stephanie R Hyslop, Marliese Alexander, Alesha A Thai, Ariena Kersbergen, Andrew J Kueh, Marco J Herold, Jason Corbin, Pradnya Gangatirkar, Ashley P Ng, Benjamin J Solomon and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Stephanie R HyslopACRF Cancer Biology & Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Marliese AlexanderPharmacy Department, Peter MacCallum Cancer Centre, University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0001-5782-7912
Alesha A ThaiDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Ariena KersbergenACRF Cancer Biology & Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Andrew J KuehDepartment of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.
Marco J HeroldDepartment of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.
Jason CorbinACRF Cancer Biology & Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Pradnya GangatirkarACRF Cancer Biology & Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.
Ashley P NgDepartment of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-9690-0879
Benjamin J SolomonSir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia.
Warren S AlexanderDepartment of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.
Kate D SutherlandACRF Cancer Biology & Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-7453-3366
Emma C JosefssonACRF Cancer Biology & Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia. josefsson@wehi.edu.au.ORCID http://orcid.org/0000-0001-6478-5204
The University of Melbourne · AUWalter and Eliza Hall Institute of Medical Research · AUPeter MacCallum Cancer Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated platelet count is associated with poor survival in certain solid cancers, including lung cancer. In addition, experimental transplantation of cancer cell lines has uncovered a role for platelets in blood-borne metastasis. These studies, however, do not account for heterogeneity between lung cancer subtypes. Subsequently, the role of platelets in the major subtypes of non-small cell lung cancer (adenocarcinoma (ADC) and squamous cell carcinoma (SqCC)) is not fully understood. We utilised an autochthonous Kras

Indexed as

Adenocarcinoma of LungAnimalsBlood PlateletsDisease Models, AnimalGenes, rasHumansMaleMice

Identifiers

PMID32535617
OpenAlexW3034911683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.