ReviewOncogene2020
The use of non-traditional models in the study of cancer resistance-the case of the naked mole rat.
Review in Oncogene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Longevity through immunity: the unusual naked mole-rat immune system.GeroScience · 2026Review
- The Paipu framework enables creation of a large-scale mammalian cancer transcriptomics atlas.bioRxiv : the preprint server for biology · 2026Article
- Article
- Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance.npj aging · 2025Article
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance.PLoS biology · 2024Article
- Evolution of T cells in the cancer-resistant naked mole-rat.Nature communications · 2024Article
- Naked mole-rat and Damaraland mole-rat exhibit lower respiration in mitochondria, cellular and organismal levels.Biochimica et biophysica acta. Bioenergetics · 2022Article
- Housing and Husbandry Alternatives for Naked Mole Rat Colonies Used in Research Settings.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- miRNAs Copy Number Variations Repertoire as Hallmark Indicator of Cancer Species Predisposition.Genes · 2022Article
- The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Article
- What Animal Cancers teach us about Human Biology.Theranostics · 2021Review
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-traditional model organisms are typically defined as any model the deviates from the typical laboratory animals, such as mouse, rat, and worm. These models are becoming increasingly important in human disease research, such as cancer, as they often display unusual biological features. Naked mole rats (NMRs) are currently one of the most popular non-traditional model, particularly in the longevity and cancer research fields. NMRs display an exceptionally long lifespan (~30 years), yet have been observed to display a low incidence of cancer, making them excellent candidates for understanding endogenous cancer resistance mechanisms. Over the past decade, many potential resistance mechanisms have been characterized. These include unique biological mechanisms involved in genome stability, protein stability, oxidative metabolism, and other cellular mechanisms such as cell cycle regulation and senescence. This review aims to summarize the many identified cancer resistance mechanisms to understand some of the main hypotheses that have thus far been generated. Many of these proposed mechanisms remain to be fully characterized or confirmed in vivo, giving the field a direction to grow and further understand the complex biology displayed by the NMR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.