Evidence map›Paper›PMID 32535547›Full record

ReviewEBioMedicine2020

Merits and culprits of immunotherapies for neurological diseases in times of COVID-19.

Marc Pawlitzki, Uwe K Zettl, Tobias Ruck, Leoni Rolfes, Hans-Peter Hartung, Sven G Meuth

Open access · goldAbstract readReview
In one paragraph

Review in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. KCell research · 2022
    Article
  10. Review
  11. Vaccination and multiple sclerosis in the era of the COVID-19 pandemic.Journal of neurology, neurosurgery, and psychiatry · 2021
    Review
  12. Ocrelizumab Extended Interval Dosing in Multiple Sclerosis in Times of COVID-19.Neurology(R) neuroimmunology & neuroinflammation · 2021
    Observational
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Marc PawlitzkiDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany. Electronic address: marc.pawlitzki@ukmuenster.de.
Uwe K ZettlDepartment of Neurology, Neuroimmunological Section, University of Rostock, Rostock, Germany.
Tobias RuckDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Leoni RolfesDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
Hans-Peter HartungDepartment of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Sven G MeuthDepartment of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany. Electronic address: sven.meuth@ukmuenster.de.
University Hospital Münster · DEHeinrich Heine University Düsseldorf · DEUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunosuppression and immunomodulation are valuable therapeutic approaches for managing neuroimmunological diseases. In times of the Coronavirus disease 2019 (COVID-19) pandemic, clinicians must deal with the question of whether immunotherapy should currently be initiated or discontinued in neurological patients. Uncertainty exists especially because different national medical associations publish different recommendations on the extent to which immunotherapies must be continued, monitored, or possibly switched during the current pandemic. Based on the most recently available data both about the novel coronavirus and the approved immunotherapies for neurological diseases, we provide an updated overview that includes current treatment strategies and the associated COVID-19 risk, but also the potential of immunotherapies to treat COVID-19.

Indexed as

ImmunotherapyAntibodies, MonoclonalBetacoronavirusComplement System ProteinsCoronavirus InfectionsCOVID-19HumansImmunity, ActiveImmunosuppressive AgentsNervous System DiseasesPandemicsPneumonia, ViralSARS-CoV-2VaccinationAntibodies, MonoclonalComplement System ProteinsImmunosuppressive AgentsCOVID-19Disease modifying therapiesImmunotherapiesInfections riskMultiple sclerosis

Identifiers

PMID32535547
PMCPMC7286830
OpenAlexW3034349557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.