Evidence map›Paper›PMID 32535541›Full record

ArticleThe International journal on drug policy2020

Trajectories of initiation for the heroin-based drug whoonga - qualitative evidence from South Africa.

Griffin A Tyree, Nzwakie Mosery, Elizabeth F Closson, Zonke Mabude, Carol du Toit, David R Bangsberg, Steven A Safren, Kenneth H Mayer, Jennifer A Smit, Matthew J Mimiaga and 1 more

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Rats chasing the dragon: A new heroin inhalation method.Journal of neuroscience methods · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Griffin A TyreeUniversity of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, United States.
Nzwakie MoseryMatCH Research Unit (MRU), Department of Obstetrics and Gynaegology, Faculty of Health Sciences, University of the Witwatersrand, 40 Dr AB Xuma Street, Suite 1108-9, Commercial City, Durban, KwaZulu-Natal 4001, South Africa.
Elizabeth F ClossonThe Fenway Institute, Fenway Health, 1340 Boylston Street, Boston, MA 02215, United States.
Zonke MabudeMatCH Research Unit (MRU), Department of Obstetrics and Gynaegology, Faculty of Health Sciences, University of the Witwatersrand, 40 Dr AB Xuma Street, Suite 1108-9, Commercial City, Durban, KwaZulu-Natal 4001, South Africa.
Carol du ToitSANCA Durban Alcohol & Drug Centres, 185 Vause Road, Durban, KwaZulu-Natal 4001, South Africa.
David R BangsbergOHSU-PSU School of Public Health, 506 SW Mill Street, Portland, OR 97201, United States.
Steven A SafrenThe Fenway Institute, Fenway Health, 1340 Boylston Street, Boston, MA 02215, United States; University of Miami, 1320 S Dixie Highway, Coral Gables, FL 33146, United States.
Kenneth H MayerThe Fenway Institute, Fenway Health, 1340 Boylston Street, Boston, MA 02215, United States; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, United States.
Jennifer A SmitMatCH Research Unit (MRU), Department of Obstetrics and Gynaegology, Faculty of Health Sciences, University of the Witwatersrand, 40 Dr AB Xuma Street, Suite 1108-9, Commercial City, Durban, KwaZulu-Natal 4001, South Africa.
Matthew J MimiagaThe Fenway Institute, Fenway Health, 1340 Boylston Street, Boston, MA 02215, United States; Brown University, School of Public Health, 121 S Main Street, Providence, RI 02903, United States; Alpert Medical School, 222 Richmond Street, Providence, RI 02903, United States.
David J GrelottiUniversity of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, United States; HIV Neurobehavioral Research Program, University of California, San Diego, 220 Dickinson Street, San Diego, CA 92103, United States. Electronic address: dgrelotti@ucsd.edu.
University of the Witwatersrand · ZAFenway Health · USLemuel Shattuck Hospital · USNeurobehavioral Research (United States) · USUniversity of California, San Diego · USUniversity of Miami · USUniversity of Portland · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core & MHD-CEP30MH133399 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI Steven A Safren · 2023 to 2026
$8.9M
UC San Diego Clinical and Translational Research InstituteTL1TR001443 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2019
$3.4M
Addressing psychosocial comorbidities in HIV treatment and preventionK24DA040489 · NIDA · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2016 to 2020
$931k
San Diego Clinical and Translational Research InstituteTL1TR000098 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$860k
Epidemiology of HIV antiretroviral exposure from whoonga use in South AfricaR21DA039857 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRELOTTI, DAVID JOHN · 2015 to 2016
$376k
NCATS NIH HHS TL1 TR000098NCATS NIH HHS TL1 TR001443NCATS NIH HHS UL1 TR001442NIAID NIH HHS P30 AI060354NIDA NIH HHS K24 DA040489NIDA NIH HHS R21 DA039857NIMH NIH HHS P30 MH133399
6 · The paper itself

Abstract

backgroundWhoonga is a smoked heroin-based street drug that first emerged in South Africa a decade ago. While previous scientific reports suggest that use is growing and youth are particularly vulnerable, trajectories of initiation are not well characterized.

methodsIn 2015, 30 men undergoing residential addiction treatment for this smoked heroin drug in KwaZulu-Natal, South Africa participated in semi-structured interviews about their experiences using the drug. Interview data were coded using qualitative content analysis.

resultsParticipant trajectories to initiating smoked heroin were "vertical" in the context of marijuana use or "horizontal" in the context of other hard drug use. Participants reporting vertical trajectories began smoking heroin as youth at school or in other settings where people were smoking marijuana. Several participants with horizontal trajectories started smoking heroin to address symptoms of other drug or alcohol addiction. Social influences on initiation emerged as an overarching theme. Members of participants' social networks who were smoking or distributing heroin figured prominently in initiation narratives. Surprisingly, references to injection drug use were absent from initiation narratives. Participants reported people who smoke heroin differ from those who inject heroin by race.

conclusionConsistent with theories implicating social and structural influences on substance use initiation, people who started smoking heroin had social contacts who smoked heroin and frequented places where substance use was common. Smoked heroin initiation for several participants with horizontal trajectories may have been averted if they accessed evidence-based treatments for stimulant or alcohol use disorders. With increasing reports of heroin use across Africa, a coordinated approach to address this growing epidemic is needed. However, because smoked heroin and injection heroin use occur in distinct risk environments, interventions tailored to people who use smoked heroin will be needed to prevent smoked heroin use, prevent transition to injection use, and mitigate other social harms.

Indexed as

AlcoholismHeroin DependenceIllicit DrugsSubstance Abuse, IntravenousAdolescentHeroinHumansMaleSouth AfricaHeroinIllicit DrugscannabisHIVnyaopeOpiateopioidrecreational use of antiretroviral medication

Identifiers

PMID32535541
PMCPMC7493467
OpenAlexW3035340043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.