Evidence map›Paper›PMID 32534985›Full record

ArticleBrain, behavior, and immunity2020

Social integration and inflammation in individuals with and without posttraumatic stress disorder.

Ashkan J Ahmadian, Joy E Lin, Thomas C Neylan, Joshua D Woolley, Aoife O'Donovan, Beth E Cohen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Social frailty and the incidence of motoric cognitive risk syndrome in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  5. Review
  6. Posttraumatic stress disorder symptoms associated with protective and risky behaviors for coronavirus disease 2019.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ashkan J AhmadianSan Francisco Veterans Affairs Medical Center and Mental Illness Research, Education and Clinical Center, San Francisco, CA, USA; Department of Internal Medicine, St. Mary's Medical Center, San Francisco, CA, USA.
Joy E LinSan Francisco Veterans Affairs Medical Center and Mental Illness Research, Education and Clinical Center, San Francisco, CA, USA; Department of Neurology, Stanford University, Palo Alto, CA, USA.
Thomas C NeylanSan Francisco Veterans Affairs Medical Center and Mental Illness Research, Education and Clinical Center, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA.
Joshua D WoolleySan Francisco Veterans Affairs Medical Center and Mental Illness Research, Education and Clinical Center, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA.
Aoife O'DonovanSan Francisco Veterans Affairs Medical Center and Mental Illness Research, Education and Clinical Center, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA.
Beth E CohenSan Francisco Veterans Affairs Medical Center and Mental Illness Research, Education and Clinical Center, San Francisco, CA, USA; Department of Internal Medicine, University of California, San Francisco, CA, USA. Electronic address: beth.cohen@ucsf.edu.

Funding

NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
Individual Variation in Effects of Traumatic Stress on Gray Matter MyelinR01MH115020 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI KAUFER, DANIELA, NEYLAN, THOMAS C · 2019 to 2023
$3.9M
Psychological Stress and Risk of Cardiovascular DiseaseK23HL094765 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COHEN, BETH · 2009 to 2013
$776k
Effects of inflammation on neural mechanisms of threat sensitivity in posttraumatic stress disorderK01MH109871 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'DONOVAN, AOIFE · 2016 to 2019
$737k
NCATS NIH HHS TL1 TR001871NHLBI NIH HHS K23 HL094765NIMH NIH HHS K01 MH109871NIMH NIH HHS R01 MH115020
6 · The paper itself

Abstract

backgroundPosttraumatic stress disorder (PTSD) is associated with increased risk for morbidity and mortality, which may be mediated through elevated inflammation. In contrast, social support appears to protect against morbidity and mortality, reduce levels of inflammation, and improve PTSD outcomes.

methodsWe examined relationships among social isolation, perceived social support, and inflammation in Veterans Affairs (VA) patients with and without PTSD. Our sample included 735 (35% PTSD+) participants from the Mind Your Heart Study (mean age = 58 ± 11; 94% male). Social isolation was assessed with the Berkman Syme Social Network Index; perceived social support with the Multidimensional Scale of Perceived Social Support; and PTSD with the Clinician Administered PTSD Scale. Inflammation was indexed by high sensitivity C-reactive protein, white blood cell count, and fibrinogen. Hierarchical linear regression was used to examine associations between social measures and inflammation. PROCESS was used to examine the interactive effects of social relationships and PTSD on inflammation.

resultsSocial isolation, but not low perceived social support, trended towards an association with elevated inflammation in the full sample. However, considering groups with and without PTSD separately, social isolation was significantly associated with all inflammatory markers among individuals without PTSD, but not among those with PTSD.

conclusionsSocial integration is associated with reduced inflammation in individuals without, but not with, PTSD. Socially integrated individuals with PTSD did not have lower levels of inflammatory markers than socially isolated individuals with PTSD.

Indexed as

Stress Disorders, Post-TraumaticVeteransAgedFemaleHumansInflammationMaleMiddle AgedSocial IntegrationSocial SupportImmune SystemInflammationPerceived Social SupportPosttraumatic Stress DisorderPTSDSocial IsolationSocial NetworkSocial Support

Identifiers

PMID32534985
PMCPMC8388310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.