ArticleBrazilian journal of otorhinolaryngology
Incomplete and late recovery of sudden olfactory dysfunction in COVID-19.
Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05461365 (Intranasal Insulin for COVID-19-related Smell Loss), which is not on this map. Cited by 42 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intranasal Insulin for COVID-19-related Smell Loss
Who cites it
42 citing papers in PubMed, 5 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Prevalence and prognosis of otorhinolaryngological symptoms in patients with COVID-19: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Pooled it
- Pooled it
- Global prevalence and pathogenesis of headache in COVID-19: A systematic review and meta-analysis.F1000Research · 2020Pooled it
- Onset and duration of symptoms of loss of smell/taste in patients with COVID-19: A systematic review.American journal of otolaryngologyPooled it
- COVID-19 sequelae in adults aged less than 50 years: A systematic review.Travel medicine and infectious diseasePooled it
- Factors associated with post-COVID-19 health conditions at a rehabilitation center: a cross-sectional study, Paraíba, Brazil, 2024.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026Article
- Article
- Survey on the Traditional Use of Medicinal Herbs in Haiti: A Study on Knowledge, Practices, and Efficacy Prevention.Plants (Basel, Switzerland) · 2024Article
- Article
- Signs and symptoms of covid - 19 in patients with a history of coronary artery bypass grafting surgery.BMC infectious diseases · 2024Article
- Intranasal insulin for COVID-19-related smell loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Could Anemia Impact the Severity of Infections? COVID-19 as an Example.F1000Research · 2024Article
- COVID-19 and Mental Health: A "Pandemic Within a Pandemic".Advances in experimental medicine and biology · 2024Review
- Recovery Patterns of COVID-19 Related Smell Disorders: An Analysis of the Available Evidence.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Olfactory dysfunction among patients with COVID-19.Saudi medical journal · 2023Article
- Neurological complications and effects of COVID-19: Symptoms and conceivable mechanisms.Brain hemorrhages · 2023Review
- Epidemiological and clinical perspectives of long COVID syndrome.American journal of medicine open · 2023Article
- Late onset and persistent parosmia and dysgeusia as neurosensorial complication by the SARS virus COV 2.Otolaryngology case reports · 2023Article
- SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways.JCI insight · 2022Article
- Post Viral Olfactory Dysfunction After SARS-CoV-2 Infection: Anticipated Post-pandemic Clinical Challenge.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSudden olfactory dysfunction is a new symptom related to COVID-19, with little data on its duration or recovery rate.
objectiveTo characterize patients with sudden olfactory dysfunction during the COVID-19 pandemic, especially their recovery data.
methodsAn online survey was conducted by the Brazilian Society of Otorhinolaryngology and Cervico-Facial Surgery, and Brazilian Academy of Rhinology, including doctors who assessed sudden olfactory dysfunction patients starting after February 1st, 2020. Participants were posteriorly asked by e-mail to verify data on the recovery of sudden olfactory loss and test for COVID-19 at the end of the data collection period.
results253 sudden olfactory dysfunction patients were included, of which 59.1% were females with median age of 36 years, with a median follow-up period of 31 days. 183 patients (72.3%) had been tested for COVID-19, and of those 145 (79.2%) tested positive. Patients that tested positive for COVID-19 more frequently showed non-specific inflammatory symptoms (89.7% vs. 73.7%; p=0.02), a lower rate of total recovery of sudden olfactory dysfunction (52.6% vs. 70.3%; p=0.05) and a longer duration to achieve total recovery (15 days vs. 10 days; p=0.0006) than the ones who tested negative for COVID-19. Considering only positive-COVID-19 patients, individuals with sudden hyposmia completely recovered more often than the ones with sudden anosmia (68.4% vs. 50.0%; p=0.04).
conclusionPositive-COVID-19 patients with sudden olfactory dysfunction showed lower total recovery rate and longer duration than negative-COVID-19 patients. Additionally, total recovery was seen more frequently in positive-COVID-19 patients with sudden hyposmia than the ones with sudden anosmia.
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Registered trials
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