ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2020
Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Differential Interactions of Tissue-Restricted Host Proteins SPLUNC1 and VAMP8 with VP3 of Human Bocaviruses 1 and 2.Pathogens (Basel, Switzerland) · 2026Article
- Human bocavirus: As an emerging respiratory pathogen.World journal of virology · 2025Review
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- Clinical characteristics and risk factors of severe bocavirus-positive pneumonia in children and a literature review.Pediatric discovery · 2025Article
- Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections.Microbiology spectrum · 2025Article
- Exploring evidence from cells to clinics: is human bocavirus a gastrointestinal pathogen or just a risk factor?Archives of virology · 2025Review
- MA104 cell line is permissive for human bocavirus 1 infection.Journal of virology · 2025Article
- Molecular epidemiological characterization of human bocavirus (HBoV) in acute respiratory infection (ARI) patients in Yucheng, China.Frontiers in public health · 2025Article
- Coxsackievirus A6 U.K. Genetic and Clinical Epidemiology Pre- and Post-SARS-CoV-2 Emergence.Pathogens (Basel, Switzerland) · 2024Article
- Microfluidic qPCR for detection of 21 common respiratory viruses in children with influenza-like illness.Scientific reports · 2024Article
- Life-Threatening Conditions in Children with Bocavirus Infection-Case Series and Mini Review of the Literature.Viruses · 2024Review
- Bocaparvovirus in infants hospitalized in a neonatal intensive care unit in Midwest Brazil during the COVID-19 pandemic (2021-2022).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Wastewater-based epidemiology applied at the building-level reveals distinct virome profiles based on the age of the contributing individuals.Human genomics · 2024Article
- Analysis of a Cohort of 165 Pediatric Patients with Human Bocavirus Infection and Comparison between Mono-Infection and Respiratory Co-Infections: A Retrospective Study.Pathogens (Basel, Switzerland) · 2024Article
- Human Bocavirus-1 infection: a closer look into its clinical and virological features.Lancet regional health. Americas · 2024Article
- Clinical and molecular characterization of children and adults with respiratory bocavirus infection in Mexico: a cross-sectional nested study within the ILI002 prospective observational study.Lancet regional health. Americas · 2024Article
- Article
- Demographic and clinical characteristics of human bocavirus-1 infection in patients with acute respiratory tract infections during the COVID-19 pandemic in the Central Province of Sri Lanka.BMC infectious diseases · 2023Article
- Human Bocavirus in Childhood: A True Respiratory Pathogen or a "Passenger" Virus? A Comprehensive Review.Microorganisms · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince its first isolation in 2005, Human Bocavirus (HBoV) has been repeatedly associated with acute respiratory tract infections, although its role in pathogenicity remains unclear due to high co-infection rates.
objectivesTo assess HBoV prevalence and associated disease in a cohort of respiratory patients in the East Midlands, UK between 2015 and 2019. STUDY
designWe initially investigated the undiagnosed burden of HBoV in a retrospective paediatric cohort sampled between 2015 and 2017 using an in-house PCR assay. HBoV was subsequently incorporated into the standard respiratory diagnostic pathway and we audited a calendar year of HBoV positive results between 2018 and 2019.
resultsOur retrospective PCR screening of previously routine diagnostic-negative samples from juvenile patients identified a 9% (n = 30) prevalence of HBoV type 1. These apparent HBoV1 mono-infections were frequently associated with respiratory tract symptoms, often severe requiring ventilation, oxygen and steroid intervention with 31% (n = 9) of individuals requiring intensive care. When HBoV screening was subsequently adopted into the routine respiratory diagnostic pathway, year-round infections were observed in both children and adults peaking in February. 185 of 9098 (2.03%) individuals were found to be HBoV positive with children aged 12-24 months the principally infected group. However, HBoV infection was also observed in patients aged over 60, predominantly as a mono-infection. 23% of the 185 unique patients were HBoV monoinfected and persistent low-level DNA positivity was observed in 15 individuals up to 6-months after initial presentation.
conclusionHBoV1 is a prevalent respiratory infection in the UK capable of causing serious monoinfections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.