ArticleDiabetes research and clinical practice2020
COVID19 in South Asians/Asian Indians: Heterogeneity of data and implications for pathophysiology and research.
Article in Diabetes research and clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Monitoring of antibodies against SARS-CoV-2 over 2 years and characterization of immune responses following Omicron infection in a South Indian community cohort.Scientific reports · 2025Article
- Genetic variants inFrontiers in genetics · 2025Article
- Knowledge mapping of trained immunity/innate immune memory: Insights from two decades of studies.Human vaccines & immunotherapeutics · 2024Review
- The Role of Age and Comorbidity Interactions in COVID-19 Mortality: Insights from Cardiac and Pulmonary Conditions.Journal of clinical medicine · 2024Article
- The role of HLA genetic variants in COVID-19 susceptibility, severity, and mortality: A global review.Journal of clinical laboratory analysis · 2024Review
- Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into Cells.Microbiology spectrum · 2022Article
- Premature mortality attributable to COVID-19: potential years of life lost in 17 countries around the world, January-August 2020.BMC public health · 2022Article
- Diagnostic Values of Laboratory Biomarkers in Predicting a Severe Course of COVID-19 on Hospital Admission.BioMed research international · 2022Article
- Host polymorphisms and COVID-19 infection.Advances in clinical chemistry · 2022Article
- Coping Strategy, Life Style and Health Status During Phase 3 of Indian National Lockdown for COVID-19 Pandemic-A Pan-India Survey.Frontiers in public health · 2022Article
- SARS-CoV-2 infection in India bucks the trend: Trained innate immunity?American journal of human biology : the official journal of the Human Biology Council · 2021Article
- Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronaviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Autoimmune inflammatory rheumatic diseases and COVID-19 outcomes in South Korea: a nationwide cohort study.The Lancet. Rheumatology · 2021Article
- A blood RNA transcriptome signature for COVID-19.BMC medical genomics · 2021Article
- COVID-19 pandemic and breast cancer management: A retrospective observational clinical study from Pakistan.Annals of medicine and surgery (2012) · 2021Article
- Ethnicity-Specific Features of COVID-19 Among Arabs, Africans, South Asians, East Asians, and Caucasians in the United Arab Emirates.Frontiers in cellular and infection microbiology · 2021Article
- Assessment and Management of Diabetic Patients During the COVID-19 Pandemic.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- SARS-CoV-2 infections in children and young people.Clinical immunology (Orlando, Fla.) · 2020Review
- Article
- COVID-19 in people living with diabetes: An international consensus.Journal of diabetes and its complications · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite a large population and limited health infrastructure, the incidence and mortality of Coronavirus Disease 2019 (COVID-19) has been lower in South Asia than many regions. The underlying reasons and mechanisms for this relative protection are not established. However both genetic and environmental factors might play a role. Polymorphisms in ACE2 gene, ACE gene and in genes for some of the host cell proteases could affect the viral entry and replication. There is some evidence that HLA polymorphisms and several pathways involved in immune and inflammatory response could contribute to ethnic variation. Cross immunity because of past exposure to viral infections as well as malaria is likely to protect from the severe manifestations of disease. Role of BCG vaccination in trained innate immunity is recognised and could be a protective factor against COVID-19. There is limited evidence of the possibility of a less virulent viral strain circulating in South Asia. There is evidence from different parts of the world that temperature and humidity can influence viral survival as well as the host immune response. Finally implementation of early containment measures by some South Asian countries has also contributed to a less disease burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.