Evidence map›Paper›PMID 32533926›Full record

ArticleThe American journal of pathology2020

Perivascular Fibro-Adipogenic Progenitor Tracing during Post-Traumatic Osteoarthritis.

Takashi Sono, Ching-Yun Hsu, Yiyun Wang, Jiajia Xu, Masnsen Cherief, Simone Marini, Amanda K Huber, Sarah Miller, Bruno Péault, Benjamin Levi and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Pirfenidone Attenuates Fibrosis and Neovascularization in 3D Spheroid-Laden Hydrogel Culture.Journal of tissue engineering and regenerative medicine · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Blood Vessel Resident Human Stem Cells in Health and Disease.Stem cells translational medicine · 2022
    Review
  14. Article
  15. Divergent effects of distinct perivascular cell subsets for intra-articular cell therapy in posttraumatic osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Takashi SonoDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland; Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ching-Yun HsuDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Yiyun WangDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Jiajia XuDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Masnsen CheriefDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Simone MariniSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
Amanda K HuberSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
Sarah MillerDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Bruno PéaultDepartment of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA and Orthopaedic Hospital, Los Angeles, California.
Benjamin LeviSection of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland; Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA and Orthopaedic Hospital, Los Angeles, California. Electronic address: awjames@jhmi.edu.
Johns Hopkins University · USUniversity of Michigan · USOrthopaedic Hospital · US

Funding

Targeting Molecular and Cellular Mediators of Inflammation to Prevent Pathologic Cell Differentiation and Heterotopic OssificationR01AR071379 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2021
$1.5M
Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
Developing New Diagnostic and Timed, TAK1 Specific Treatment Strategies for Trauma Induced Heterotopic OssificationR01GM123069 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2017 to 2020
$1.2M
NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
Role of sensory nerves in cranial bone repairR21DE027922 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CLEMENS, THOMAS L, JAMES, AARON W · 2018 to 2019
$450k
Medical Research Council G1000816NIAMS NIH HHS K08 AR068316NIAMS NIH HHS R01 AR070773NIAMS NIH HHS R01 AR071379NIDCR NIH HHS R21 DE027922NIGMS NIH HHS R01 GM123069
6 · The paper itself

Abstract

Perivascular mural cells surround capillaries and microvessels and have diverse regenerative or fibrotic functions after tissue injury. Subsynovial fibrosis is a well-known pathologic feature of osteoarthritis, yet transgenic animals for use in visualizing perivascular cell contribution to fibrosis during arthritic changes have not been developed. Here, inducible Pdgfra-CreER

Indexed as

AdipocytesAdipose TissueAnimalsCell LineageFibroblastsKnee JointMiceMice, TransgenicOsteoarthritisStem Cells

Identifiers

PMID32533926
PMCPMC7456743
OpenAlexW3034584609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.