Evidence map›Paper›PMID 32533923›Full record

ArticleCell host & microbe2020

Acetylation of Cytidine Residues Boosts HIV-1 Gene Expression by Increasing Viral RNA Stability.

Kevin Tsai, Ananda Ayyappan Jaguva Vasudevan, Cecilia Martinez Campos, Ann Emery, Ronald Swanstrom, Bryan R Cullen

Open access · bronzeAbstract read
In one paragraph

Article in Cell host & microbe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 183 citations in OpenAlex.

  1. Article
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  7. NAT10-mediated acCellular & molecular biology letters · 2026
    Article
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  13. Article
  14. The NAT10/acCell communication and signaling : CCS · 2026
    Review
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  16. Article
  17. Article
  18. Article
  19. Identification of the Role ofVeterinary sciences · 2025
    Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kevin TsaiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Ananda Ayyappan Jaguva VasudevanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Cecilia Martinez CamposDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Ann EmeryLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ronald SwanstromLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Bryan R CullenDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: bryan.cullen@duke.edu.
Duke Medical Center · USUniversity of North Carolina at Chapel Hill · USDuke University Hospital · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5M
The Center for HIV RNA Studies (CRNA)U54AI150470 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHIU, WAH · 2019 to 2021
$15.1M
Epitranscriptomic modification of HIV-1 transcripts: Effects of drugs of abuseR01DA046111 · NIDA · DUKE UNIVERSITY · PI CULLEN, BRYAN R. · 2018 to 2022
$1.6M
NCI NIH HHS P30 CA016086NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI064518NIAID NIH HHS U54 AI150470NIDA NIH HHS R01 DA046111
6 · The paper itself

Abstract

Epitranscriptomic RNA modifications, including methylation of adenine and cytidine residues, are now recognized as key regulators of both cellular and viral mRNA function. Moreover, acetylation of the N

Indexed as

AcetylationCell LineCytidineFemaleGene ExpressionGene Expression Regulation, ViralHEK293 CellsHIV-1HumansHydrazonesMaleN-Terminal AcetyltransferasesRNA StabilityRNA, ViralThiazolesVirus Replication4-(4-cyanophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazoleCytidineHydrazonesNAT10 protein, humanN-Terminal AcetyltransferasesRNA, ViralThiazolesac4Cepitranscriptomicgene regulationHIV-1human immunodeficiency virus 1N4-acetylcytidineN-acetyltransferase 10NAT10retrovirusRNA modificationvirus

Identifiers

PMID32533923
PMCPMC7429276
OpenAlexW3034750978

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.