Evidence map›Paper›PMID 32533862›Full record

ArticleJournal of pineal research2020

Resource: A multi-species multi-timepoint transcriptome database and webpage for the pineal gland and retina.

Eric Chang, Cong Fu, Steven L Coon, Shahar Alon, Marjan Bozinoski, Matthew Breymaier, Diego M Bustos, Samuel J Clokie, Yoav Gothilf, Caroline Esnault and 9 more

Abstract read
In one paragraph

Article in Journal of pineal research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Pineal Transcriptome Webpage.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  6. Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Eric ChangBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Cong FuSection on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Steven L CoonSection on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-5233-0277
Shahar AlonDepartment of Neurobiology, The George S. Wise Faculty of Life Sciences, and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel.
Marjan BozinoskiDepartment of Physiology and Biophysics and the Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.
Matthew BreymaierComputer Support Services Core, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Diego M BustosSection on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Samuel J ClokieSection on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Yoav GothilfDepartment of Neurobiology, The George S. Wise Faculty of Life Sciences, and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel.
Caroline EsnaultBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
P Michael IuvoneDepartments of Ophthalmology and Pharmacology & Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.
Christopher E MasonDepartment of Physiology and Biophysics and the Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.
Margaret J OchocinskaSection on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Adi TovinDepartment of Neurobiology, The George S. Wise Faculty of Life Sciences, and Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel.
Charles WangCenter for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.
Pinxian XuDepartment of Genetics and Genomic Sciences, Mount Sinai School of Medicine Icahn Medical Institute, New York, NY, USA.
Jinhang ZhuUnited States Food and Drug Administration's National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA.
Ryan DaleBioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
David C KleinSection on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-1792-5806

Funding

Molecular Genomics Sequencing Core FacilityZICHD008958 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI MAHADEVAN, VIVEK · 2016 to 2025
$19.0M
NICHD Bioinformatics and Scientific Programming CoreZICHD008986 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DALE, RYAN · 2019 to 2025
$17.4M
Pineal Regulation: Developmental and Circadian Changes in the Transcriptome ZIAHD008836 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KLEIN, DAVID · 2009 to 2015
$2.4M
Pineal Regulation: Neural, transsynaptic and intracellular control mechanismsZIAHD008838 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KLEIN, DAVID · 2009 to 2015
$2.1M
Pineal Regulation: Control of arylalkylamine N-acetyltransferaseZ01HD008836 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KLEIN, DAVID · 2007 to 2008
$2.0M
Pineal Regulation: Molecular basis of developmentZIAHD008837 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KLEIN, DAVID · 2009 to 2015
$1.8M
Pineal Regulation: Molecular basis of development Z01HD008837 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KLEIN, DAVID · 2007 to 2008
$1.2M
Pineal Regulation: Neural, transsynaptic and intracellular controlZ01HD008838 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KLEIN, DAVID · 2007 to 2008
$1.2M
Eunice Kennedy Shriver National Institute of Child Health and Human Development HD008836Eunice Kennedy Shriver National Institute of Child Health and Human Development HD008837Eunice Kennedy Shriver National Institute of Child Health and Human Development HD008838Eunice Kennedy Shriver National Institute of Child Health and Human Development HD008950Eunice Kennedy Shriver National Institute of Child Health and Human Development HD008986Intramural NIH HHS Z01 HD008836Intramural NIH HHS Z01 HD008837Intramural NIH HHS Z01 HD008838Intramural NIH HHS ZIA HD008836Intramural NIH HHS ZIA HD008837Intramural NIH HHS ZIA HD008838The National Natural Science Foundation of China 31401080United States-Israel Binational Science Foundation 2009290
6 · The paper itself

Abstract

The website and database https://snengs.nichd.nih.gov provides RNA sequencing data from multi-species analysis of the pineal glands from zebrafish (Danio rerio), chicken (White Leghorn), rat (Rattus novegicus), mouse (Mus musculus), rhesus macaque (Macaca mulatta), and human (Homo sapiens); in most cases, retinal data are also included along with results of the analysis of a mixture of RNA from tissues. Studies cover day and night conditions; in addition, a time series over multiple hours, a developmental time series and pharmacological experiments on rats are included. The data have been uniformly re-processed using the latest methods and assemblies to allow for comparisons between experiments and to reduce processing differences. The website presents search functionality, graphical representations, Excel tables, and track hubs of all data for detailed visualization in the UCSC Genome Browser. As more data are collected from investigators and improved genomes become available in the future, the website will be updated. This database is in the public domain and elements can be reproduced by citing the URL and this report. This effort makes the results of 21st century transcriptome profiling widely available in a user-friendly format that is expected to broadly influence pineal research.

Indexed as

Databases, Nucleic AcidGene Expression RegulationInternetAnimalsChickensHumansMacaca mulattaMicePineal GlandRatsRetinaZebrafishbiological rhythmsneurotranscriptomicspinealretinaRNA-Seqtranscriptomewebpage

Identifiers

PMID32533862
PMCPMC7513311

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.