Evidence map›Paper›PMID 32533754›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Photoactivated Polymersome Nanomotors: Traversing Biological Barriers.

Jingxin Shao, Shoupeng Cao, David S Williams, Loai K E A Abdelmohsen, Jan C M van Hest

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 131 citations in OpenAlex.

  1. Review
  2. Programmable Nanoscale Motion via Molecular Patterning on DNA Origami.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Article
  5. Engineering Motile Coacervate Droplets via Nanomotor Stabilization.Journal of the American Chemical Society · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Photothermal Cavitation-Driven Micromotor to Penetrate Cell Membrane.Journal of the American Chemical Society · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Swarms of Enzymatic Nanobots for Efficient Gene Delivery.ACS applied materials & interfaces · 2024
    Article
  17. Article
  18. Article
  19. Putting Hybrid Nanomaterials to Work for Biomedical Applications.Angewandte Chemie (International ed. in English) · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jingxin ShaoBio-Organic Chemistry, Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Helix (STO 3.41), P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Shoupeng CaoBio-Organic Chemistry, Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Helix (STO 3.41), P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
David S WilliamsDepartment of Chemistry, College of Science, Swansea University, Swansea, SA2 8PP, UK.
Loai K E A AbdelmohsenBio-Organic Chemistry, Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Helix (STO 3.41), P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Jan C M van HestBio-Organic Chemistry, Institute of Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Helix (STO 3.41), P. O. Box 513, 5600 MB, Eindhoven, The Netherlands.ORCID 0000-0001-7973-2404
Eindhoven University of Technology · NLSwansea University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic nanomotors are appealing delivery vehicles for the dynamic transport of functional cargo. Their translation toward biological applications is limited owing to the use of non-degradable components. Furthermore, size has been an impediment owing to the importance of achieving nanoscale (ca. 100 nm) dimensions, as opposed to microscale examples that are prevalent. Herein, we present a hybrid nanomotor that can be activated by near-infrared (NIR)-irradiation for the triggered delivery of internal cargo and facilitated transport of external agents to the cell. Utilizing biodegradable poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) block copolymers, with the two blocks connected via a pH sensitive imine bond, we generate nanoscopic polymersomes that are then modified with a hemispherical gold nanocoat. This Janus morphology allows such hybrid polymersomes to undergoing photothermal motility in response to thermal gradients generated by plasmonic absorbance of NIR irradiation, with velocities ranging up to 6.2±1.10 μm s

Indexed as

Cell MembraneGoldHeLa CellsHumansHydrogen-Ion ConcentrationInfrared RaysMetal NanoparticlesParticle SizePhotochemical ProcessesPolymersSurface PropertiesGoldPolymersintracellular deliverynanomotorsphotothermal effectpH-sensitive polymerpolymersomes

Identifiers

PMID32533754
PMCPMC7540338
OpenAlexW3034364980

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.