ArticleImmunity, inflammation and disease2020
Seasonality of allergic diseases: Real-world evidence from a nationwide population-based study.
Article in Immunity, inflammation and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Prevalence and characteristics of allergic disease among pediatric patients of urban, rural, and remote primary care clinics: A multisite study in the Philippines.Asia Pacific allergy · 2026Article
- A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.Frontiers in immunology · 2026Article
- Seasonal Changes in the Severity of Atopic Dermatitis by Birth Season: A Pilot Prospective Cohort Study.Acta dermato-venereologica · 2025Article
- Article
- Comorbid asthma is associated with rhinitis severity in children exposed to air pollutants.Pediatric research · 2024Article
- Immunologic, genetic, and ecological interplay of factors involved in allergic diseases.Frontiers in allergy · 2023Review
- Effect of Dosing Interval on Compliance of Osteoporosis Patients on Bisphosphonate Therapy: Observational Study Using Nationwide Insurance Claims Data.Journal of clinical medicine · 2021Article
- Air pollution and meteorological conditions significantly contribute to the worsening of allergic conjunctivitis: a regional 20-city, 5-year study in Northeast China.Light, science & applications · 2021Article
- Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016-2018: a multicenter, retrospective study.BMC pediatrics · 2021Article
- Seasonality of allergic diseases: Real-world evidence from a nationwide population-based study.Immunity, inflammation and disease · 2020Article
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4 authors.
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Abstract
introductionSeasonal variations of allergic diseases have been of great interest in clinical practice, but large-scale epidemiological data in the real world is lacking.
methodsWe conducted a nationwide, population-based, cross-sectional study using the Korean National Health Insurance claims database to examine the seasonalities of allergic rhinitis (AR), asthma, allergic conjunctivitis (AC), and atopic dermatitis (AD). In addition, we investigated the correlations between the monthly patient numbers of each disease and climate factors such as daytime length, temperature, daily temperature range, humidity, solar radiation, rainfall, UVA dose, UVB dose, and PM10.
resultsThe highest seasonal variation was identified in AC, followed by AR, asthma, and AD. AR was most prevalent in September and least prevalent in July and was positively correlated with a daily temperature range. Asthma had peaked in the winter and spring and was negatively correlated with both temperature and humidity. AC had dual peaks in May and September and the valley in winter. AD was prevalent between May and August with the lowest visits in winter and positively correlated with temperature.
conclusionsWe demonstrated a clear seasonality of four allergic diseases. Korea is located in a temperate region with four distinct seasons, with 50 million people all having a single health insurance system. Therefore, our data reflects all hospital visits in Korea with the least chance for selection bias.
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