ArticleJournal of clinical monitoring and computing2021
Performance of closed-loop resuscitation in a pig model of haemorrhagic shock with fluid alone or in combination with norepinephrine, a pilot study.
Article in Journal of clinical monitoring and computing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Computer-assisted Individualized Hemodynamic Management Reduces Intraoperative Hypotension in Intermediate- and High-risk Surgery: A Randomized Controlled Trial.Anesthesiology · 2021Trial
- Comparison of Controller Logics for Automating Vasopressor Administration Using a Hardware-in-Loop Test Platform.Bioengineering (Basel, Switzerland) · 2026Article
- Development of a vasopressor control module for testing hemorrhagic shock resuscitation controllers.Biomedical engineering online · 2026Article
- Automated pneumatic tourniquet for hemorrhage control evaluated using an adaptive testing platform.Frontiers in medical technology · 2026Article
- The Development of an Automated Fluid Infusion Management System to Prevent Hypotension During General Anesthesia: A Randomized Clinical Trial.Journal of clinical medicine · 2025Article
- Initial management of haemorrhagic war casualties: tactical priorities and innovative approaches in modern and future warfare.Critical care (London, England) · 2025Review
- Closed-loop anesthesia: foundations and applications in contemporary perioperative medicine.Journal of clinical monitoring and computing · 2024Review
- Closing the loop: automation in anesthesiology is coming.Journal of clinical monitoring and computing · 2024Article
- Computer-controlled closed-loop norepinephrine infusion system for automated control of mean arterial pressure in dogs under isoflurane-induced hypotension: a feasibility study.Frontiers in veterinary science · 2024Article
- Article
- Systolic Arterial Pressure Control Using an Automated Closed-Loop System for Vasopressor Infusion during Intermediate-to-High-Risk Surgery: A Feasibility Study.Journal of personalized medicine · 2022Article
- Hardware-in-Loop Comparison of Physiological Closed-Loop Controllers for the Autonomous Management of Hypotension.Bioengineering (Basel, Switzerland) · 2022Article
- Closed-Loop Controlled Fluid Administration Systems: A Comprehensive Scoping Review.Journal of personalized medicine · 2022Article
- What is new in hemodynamic monitoring and management?Journal of clinical monitoring and computing · 2022Review
- Hemodynamic Effects of Cardiovascular Medications in a Normovolemic and Hemorrhaged Yorkshire-cross Swine Model.Comparative medicine · 2022Article
- Closed-Loop Control for Fluid Resuscitation: Recent Advances and Future Challenges.Frontiers in veterinary science · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the performance of a new device to control the administration of fluid alone or co-administration of fluid and norepinephrine in a pig model of haemorrhagic shock in two sets of experiments. In the first one, resuscitation was guided using continuous arterial pressure measurements (three groups: resuscitation with fluid by a physician, CL resuscitation with fluid, and CL resuscitation with fluid and norepinephrine). In the second one, resuscitation was guided using discontinuous arterial pressure measurements (three groups: CL resuscitation with fluid alone, CL resuscitation with fluid and moderate dose norepinephrine, and CL resuscitation with fluid and a high dose of norepinephrine). Pigs were resuscitated for 1 h. In the first set of experiments, proportion of time spent in the target area of 78-88 mmHg of systolic arterial pressure was not statistically different between the three groups: manual, 71.2% (39.1-80.1); CL with fluid, 87.8% (68.3-97.4); and CL with fluid and norepinephrine, 78.1% (59.2-83.6), p = 0.151. In the second set of experiments, performance of CL resuscitation with fluid or with combination of fluid and high or moderate dose of norepinephrine was not significantly different (p = 0.543 for time in target). Pigs resuscitated with norepinephrine required less fluid and had less haemodilution than pigs resuscitated with fluid alone. Performance of CL resuscitation using continuous arterial pressure measurement was not significantly different than optimised manual treatment by a dedicated physician. Performance of CL resuscitation was reduced with discontinuous arterial pressure measurements in comparison with continuous arterial pressure measurements.
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