ArticleBiomechanics and modeling in mechanobiology2020
Modeling intracranial aneurysm stability and growth: an integrative mechanobiological framework for clinical cases.
Article in Biomechanics and modeling in mechanobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05526352 (@neurIST), which is not on this map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
@neurIST : Informatique biomédicale intégrée Pour la Gestion Des anévrismes cérébraux
Who cites it
6 citing papers in PubMed.
- Load Transfer along Continuous Collagen Fibers Reduces the Importance of Wall Thickness Variations.ArXiv · 2025Article
- Multiscale Kinematic Growth Coupled With Mechanosensitive Systems Biology in Open-Source Software.Journal of biomechanical engineering · 2025Article
- FSGe: A fast and strongly-coupled 3D fluid-solid-growth interaction method.Computer methods in applied mechanics and engineering · 2024Article
- Comapping Cellular Content and Extracellular Matrix with Hemodynamics in Intact Arterial Tissues Using Scanning Immunofluorescent Multiphoton Microscopy.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2024Article
- A constrained mixture-micturition-growth (CMMG) model of the urinary bladder: Application to partial bladder outlet obstruction (BOO).Journal of the mechanical behavior of biomedical materials · 2022Article
- In vivo development of tissue engineered vascular grafts: a fluid-solid-growth model.Biomechanics and modeling in mechanobiology · 2022Article
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Authors and funding
4 authors.
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Abstract
We present a novel patient-specific fluid-solid-growth framework to model the mechanobiological state of clinically detected intracranial aneurysms (IAs) and their evolution. The artery and IA sac are modeled as thick-walled, non-linear elastic fiber-reinforced composites. We represent the undulation distribution of collagen fibers: the adventitia of the healthy artery is modeled as a protective sheath whereas the aneurysm sac is modeled to bear load within physiological range of pressures. Initially, we assume the detected IA is stable and then consider two flow-related mechanisms to drive enlargement: (1) low wall shear stress; (2) dysfunctional endothelium which is associated with regions of high oscillatory flow. Localized collagen degradation and remodelling gives rise to formation of secondary blebs on the aneurysm dome. Restabilization of blebs is achieved by remodelling of the homeostatic collagen fiber stretch distribution. This integrative mechanobiological modelling workflow provides a step towards a personalized risk-assessment and treatment of clinically detected IAs.
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Registered trials
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