Evidence map›Paper›PMID 32533380›Full record

ArticleAnnals of intensive care2020

Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial.

Shih-Hong Chen, Wing-Sum Chan, Chih-Min Liu, Ching-Tang Chiu, Anne Chao, Vin-Cent Wu, Wang-Huei Sheng, Chien-Heng Lai, Ming-Jiuh Wang, Yu-Chang Yeh

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01756755 (The Effect of Endotoxin Adsorber Hemoperfusion on the Microcirculation in Patients With Severe Sepsis and Septic Shock), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01756755 nacompletednot on this map

The Effect of Endotoxin Adsorber Hemoperfusion on the Microcirculation in Patients With Severe Sepsis and Septic Shock

TypeinterventionalSponsorNational Taiwan University HospitalRan2012 to 2019Enrolled29ConditionsSepsisArmsPMX-20R Hemoperfusion
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Shih-Hong ChenDepartment of Anesthesiology, Taipei Tzu Chi Hospital, No. 289, Jianguo Rd., New Taipei, Taiwan.
Wing-Sum ChanDepartment of Anesthesiology, Far Eastern Memorial Hospital, No. 21, Sec. 2, Nanya S. Rd., New Taipei, Taiwan.
Chih-Min LiuDepartment of Anesthesiology, National Taiwan University Hospital, No 7, Chung Shang South Road, Taipei, Taiwan.
Ching-Tang ChiuDepartment of Anesthesiology, National Taiwan University Hospital, No 7, Chung Shang South Road, Taipei, Taiwan.
Anne ChaoDepartment of Anesthesiology, National Taiwan University Hospital, No 7, Chung Shang South Road, Taipei, Taiwan.
Vin-Cent WuDepartment of Internal Medicine, National Taiwan University Hospital, No 7, Chung Shang South Road, Taipei, Taiwan.
Wang-Huei ShengDepartment of Internal Medicine, National Taiwan University Hospital, No 7, Chung Shang South Road, Taipei, Taiwan.
Chien-Heng LaiDepartment of Surgery, National Taiwan University Hospital, No 7, Chung Shang South Road, Taipei, Taiwan.
Ming-Jiuh WangDepartment of Anesthesiology, National Taiwan University Hospital, No 7, Chung Shang South Road, Taipei, Taiwan.
Yu-Chang YehDepartment of Anesthesiology, National Taiwan University Hospital, No 7, Chung Shang South Road, Taipei, Taiwan. tonyyeh@ntuh.gov.tw.ORCID http://orcid.org/0000-0001-5143-5520
National Taiwan University Hospital · TWFar Eastern Memorial Hospital · TWNational Tsing Hua University · TW

Funding

National Taiwan University Hospital 105-A125
6 · The paper itself

Abstract

backgroundEndotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and septic shock, and a rat sepsis model revealed that PMX-HP treatment can maintain a better microcirculation. The primary aim of this study was to investigate the effect of PMX-HP on microcirculation in patients with septic shock.

methodsPatients with septic shock were enrolled and randomized to control and PMX-HP groups. In the PMX-HP group, patients received the first session of PMX-HP in addition to conventional septic shock management within 24 h after the onset of septic shock; the second session of PMX-HP was provided after another 24 h as needed.

resultsOverall, 28 patients finished the trial and were analyzed. The mean arterial pressure and norepinephrine infusion dose did not differ significantly between the control and PMX-HP groups after PMX-HP treatment. At 48 h after enrollment, total vessel density (TVD) and perfused vessel density (PVD) were higher in the PMX-HP group than in the control group [TVD 24.2 (22.1-24.9) vs. 21.1 (19.9-22.9) mm/mm

conclusionsThis preliminary study observed that PMX-HP treatment improved microcirculation but not clinical outcomes in patients with septic shock at a low risk of mortality. Nevertheless, larger multicenter trials are needed to confirm the effect of PMX-HP treatment on microcirculation in patients with septic shock at intermediate- and high-risk of mortality. Trial registration ClinicalTrials.gov protocol registration ID: NCT01756755. Date of registration: December 27, 2012. First enrollment: October 6, 2013. https://clinicaltrials.gov/ct2/show/NCT01756755.

Indexed as

EndotoxinMicrocirculationSeptic shock

Identifiers

PMID32533380
PMCPMC7290141
OpenAlexW3035747478

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.