Evidence map›Paper›PMID 32533210›Full record

ArticlePsychopharmacology2020

Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats.

Danielle J Houwing, Jolien de Waard, Anouschka S Ramsteijn, Tom Woelders, Sietse F de Boer, Emma J Wams, Jocelien D A Olivier

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Danielle J HouwingDepartment of Neurobiology, unit Behavioral Neuroscience, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-9585-2542
Jolien de WaardDepartment of Neurobiology, unit Behavioral Neuroscience, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands.
Anouschka S RamsteijnDepartment of Neurobiology, unit Behavioral Neuroscience, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands.
Tom WoeldersDepartment of Neurobiology, unit Chronobiology, GELIFES, Univ. Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands.
Sietse F de BoerDepartment of Neurobiology, unit Behavioral Neuroscience, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands.
Emma J WamsDepartment of Neurobiology, unit Behavioral Neuroscience, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands.
Jocelien D A OlivierDepartment of Neurobiology, unit Behavioral Neuroscience, GELIFES, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, the Netherlands. j.d.a.olivier@rug.nl.
University of Groningen · NL

Funding

Dobberke Foundation UPS/BP/4151 2016-27
6 · The paper itself

Abstract

rationaleSelective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (SCN) is known to be modulated by serotonin and it is therefore assumed that SSRIs may affect circadian rhythms. However, effects of perinatal SSRI treatment on circadian system functioning in the offspring are largely unknown.

objectiveOur aim was to investigate the effects of perinatal exposure to the SSRI fluoxetine (FLX) on circadian behavior, affective behavior, and 5-HT

resultsPerinatal FLX exposure shortened the free-running tau in response to the 5-HT

conclusionsPerinatal FLX exposure altered the response to a phase-shifting challenge in female rats, whether this may pose health risks remains to be investigated.

Indexed as

8-Hydroxy-2-(di-n-propylamino)tetralinAdaptation, PsychologicalAnimalsAntidepressive AgentsCircadian RhythmFemaleFluoxetineRatsRats, TransgenicRats, WistarSelective Serotonin Reuptake InhibitorsSerotoninSuprachiasmatic Nucleus8-Hydroxy-2-(di-n-propylamino)tetralinAntidepressive AgentsFluoxetineSelective Serotonin Reuptake InhibitorsSerotonin5-HT1A receptorAnxietyCircadian behaviorClock genesCoping styleFluoxetineHypothermiaPerinatalPregnancy

Identifiers

PMID32533210
PMCPMC7351858
OpenAlexW3035711265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.