ArticleNature communications2020
MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 151 citations in OpenAlex.
- PDK1-mediated PI3K/Akt signaling regulates metabolic and developmental programs in a cosmopolitan pest.Pest management science · 2026Article
- Down-regulation of the PxJHE2 gene elevates juvenile hormone titers and compensates for fitness costs of Bt Cry1Ac resistance in Plutella xylostella (L.).Pest management science · 2026Article
- Calcineurin-dependent 20E signaling pathway enhances attacin expression to prime the immunity of Helicoverpa armigera against Bacillus thuringiensis Cry1Ac toxin.PLoS pathogens · 2026Article
- A self-attention-based deep learning model for identifying key genes in insect pupal metamorphosis.BMC genomics · 2026Article
- A second locus associated with high-level resistance to Bt Cry1Ac inApplied and environmental microbiology · 2026Article
- Genomic Insights into Local Adaptation and Evolutionary Trajectories ofBiomolecules · 2026Article
- Review
- From gatekeeper to target: MAPK cascades as control circuits at the insect-microbe interface.FEMS microbiology reviews · 2026Review
- Chemical defense mechanisms of soybean genotypes against lepidopterans.Frontiers in plant science · 2026Review
- Investigating the alleviatory ability of bio-synthesized zinc oxide nanoparticles from Sargassum ilicifolium (Turner) C. Agardh on the tomato plants exposed to whitefly infestation.Scientific reports · 2025Article
- Cuticle thickening mediates insecticide penetration resistance in Spodoptera litura.Journal of advanced research · 2025Article
- Akt-FoxO signaling drives co-adaptation to insecticide and host plant stresses in an herbivorous insect.Journal of advanced research · 2025Article
- Juvenile hormone and BMP signaling modulate fat body cell fate during the transition of previtellogenic development to vitellogenesis.BMC biology · 2025Article
- Interactions between insecticidal cry toxins and their receptors.Current genetics · 2025Review
- CRISPR/Cas Technology in Insect Insecticide Resistance.Insects · 2025Review
- The role of GPI-anchored membrane-bound alkaline phosphatase in the mode of action of Bt Cry1A toxins in the diamondback moth.Fundamental research · 2025Article
- RNA modifications in plant biotic interactions.Plant communications · 2025Review
- Knockdown of an ATP-binding cassette transporter in resistant western corn rootworm larvae partially reverses resistance to eCry3.1Ab protein.Scientific reports · 2024Article
- A midgut transcriptional regulatory loop favors an insect host to withstand a bacterial pathogen.Innovation (Cambridge (Mass.)) · 2024Article
- The recombinant jasmonate ZIM-domain (JAZ) protein functions as a novel insecticidal protein against Lepidopteran pests.Science China. Life sciences · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The arms race between entomopathogenic bacteria and their insect hosts is an excellent model for decoding the intricate coevolutionary processes of host-pathogen interaction. Here, we demonstrate that the MAPK signaling pathway is a general switch to trans-regulate differential expression of aminopeptidase N and other midgut genes in an insect host, diamondback moth (Plutella xylostella), thereby countering the virulence effect of Bacillus thuringiensis (Bt) toxins. Moreover, the MAPK cascade is activated and fine-tuned by the crosstalk between two major insect hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH) to elicit an important physiological response (i.e. Bt resistance) without incurring the significant fitness costs often associated with pathogen resistance. Hormones are well known to orchestrate physiological trade-offs in a wide variety of organisms, and our work decodes a hitherto undescribed function of these classic hormones and suggests that hormonal signaling plasticity is a general cross-kingdom strategy to fend off pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.