ArticleNature communications2020
Sub-nanowatt microfluidic single-cell calorimetry.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed.
- Direct quantification of the metabolic heat output of individual Drosophila brains.Cell reports methods · 2026Article
- Chip Calorimetry for Single-Cell Analysis: Advances, Challenges, and Opportunities.Sensors (Basel, Switzerland) · 2026Review
- Optically Detected Magnetic Resonance Based Intracellular Thermometry Using Nanodiamonds Implanted in Adherent Cancer Cells.ACS applied nano materials · 2026Article
- High-throughput chip-calorimeter using a BiMicrosystems & nanoengineering · 2025Article
- Ultra-High Sensitivity, Wide-Range Thermometry Based on High-Quality Microscale Diamond Resonators.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Picoliter-Volume Isothermal Titration Calorimetry Using Parylene Chip Calorimeter Integrated with on-Demand Droplet Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Exploring the Frontiers of Cell Temperature Measurement and Thermogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Energy partitioning in the cell cortex.Nature physics · 2024Article
- The development of ultrasensitive microcalorimeters for bioanalysis and energy balance monitoring.Fundamental research · 2024Review
- Nanomechanical thermometry for probing sub-nW thermal transport.Microsystems & nanoengineering · 2024Article
- Micro-kelvin temperature-stable system for biocalorimetry applications.The Review of scientific instruments · 2024Article
- How much heat does non-photochemical quenching produce?Frontiers in plant science · 2024Article
- AC/DC Thermal Nano-Analyzer Compatible with Bulk Liquid Measurements.Nanomaterials (Basel, Switzerland) · 2022Article
- A High-Throughput MEMS-Based Differential Scanning Calorimeter for Direct Thermal Characterization of Antibodies.Biosensors · 2022Article
- A Micromachined Picocalorimeter Sensor for Liquid Samples with Application to Chemical Reactions and Biochemistry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive and label-free calorimetry could become a disruptive technique to study single cell metabolic heat production without altering the cell behavior, but it is currently limited by insufficient sensitivity. Here, we demonstrate microfluidic single-cell calorimetry with 0.2-nW sensitivity, representing more than ten-fold enhancement over previous record, which is enabled by (i) a low-noise thermometry platform with ultralow long-term (10-h) temperature noise (80 μK) and (ii) a microfluidic channel-in-vacuum design allowing cell flow and nutrient delivery while maintaining a low thermal conductance of 2.5 μW K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.