Evidence map›Paper›PMID 32532836›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Immune Autoregulatory CD8 T Cells Require IFN-γ Responsiveness to Optimally Suppress Central Nervous System Autoimmunity.

Alexander W Boyden, Ashley A Brate, Laura M Stephens, Nitin J Karandikar

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Myelin-reactive CD8Journal of neuroinflammation · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. A Functionally Distinct CXCR3Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexander W BoydenDepartment of Pathology, University of Iowa Health Care, Iowa City, IA 52242.ORCID 0000-0003-3440-7848
Ashley A BrateDepartment of Pathology, University of Iowa Health Care, Iowa City, IA 52242.
Laura M StephensInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242.
Nitin J KarandikarDepartment of Pathology, University of Iowa Health Care, Iowa City, IA 52242; nitin-karandikar@uiowa.edu.ORCID 0000-0002-6867-6950
University of Iowa · USVeterans Health Administration · US

Funding

Immune Dysregulation During Multiple Sclerosis RelapseR01AI121567 · NIAID · UNIVERSITY OF IOWA · PI KARANDIKAR, NITIN J · 2016 to 2020
$3.8M
CNS-SPECIFIC REGULATORY CD8+ T CELLS IN AUTOIMMUNE DEMYELINATIONR01AI092106 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI KARANDIKAR, NITIN J · 2011 to 2015
$1.7M
Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating DiseaseI01BX003677 · VA · IOWA CITY VA MEDICAL CENTER · PI KARANDIKAR, NITIN J · 2017 to 2025
–
BLRD VA I01 BX003677NIAID NIH HHS R01 AI092106NIAID NIH HHS R01 AI121567
6 · The paper itself

Abstract

Investigating the complex cellular interplay controlling immunopathogenic and immunoregulatory responses is critical for understanding multiple sclerosis (MS) and for developing successful immunotherapies. Our group has demonstrated that CNS myelin-specific CD8 T cells unexpectedly harbor immune regulatory capacity in both mouse and human. In particular, PLP

Indexed as

AnimalsAutoantigensAutoimmunityCD8-Positive T-LymphocytesCells, CulturedCentral Nervous SystemDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansImmune ToleranceInterferon-gammaInterferon gamma ReceptorMiceMice, Inbred C57BLMice, KnockoutAutoantigensInterferon-gammaInterferon gamma ReceptorMyelin Proteolipid Proteinmyelin proteolipid protein (178-191)Peptide FragmentsReceptors, Interferon

Identifiers

PMID32532836
PMCPMC7343581
OpenAlexW3035351781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.