Evidence map›Paper›PMID 32532815›Full record

ArticleThe Journal of biological chemistry2020

Phosphorylation of α-dystrobrevin is essential for αkap accumulation and acetylcholine receptor stability.

Po-Ju Chen, Diego Zelada, Dina Cheryne Belhasan, Mohammed Akaaboune

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. A link between agrin signalling and CaScientific reports · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Po-Ju ChenDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.
Diego ZeladaDepartment of Cell Biology, Universidad de Concepción, Concepción, Chile.
Dina Cheryne BelhasanDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8137-1385
Mohammed AkaabouneDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA makaabou@umich.edu.ORCID 0000-0003-1991-0963
University of Michigan · USUniversity of Concepción · CL

Funding

The Dynamics of Synaptic Component at the Neuromuscular Junction of Living AnimalR01NS047332 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKAABOUNE, MOHAMMED · 2003 to 2013
$2.7M
The effect of muscle-specific anchoring protein on the biology of the Neuromuscular systemR01NS111041 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKAABOUNE, MOHAMMED · 2019 to 2024
$2.1M
Acetylcholine Receptor Stability at the Neuromuscular SystemR56NS103845 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKAABOUNE, MOHAMMED · 2018 to 2018
$532k
NINDS NIH HHS R01 NS047332NINDS NIH HHS R01 NS111041NINDS NIH HHS R56 NS103845
6 · The paper itself

Abstract

The maintenance of a high density of the acetylcholine receptor (AChR) is the hallmark of the neuromuscular junction. Muscle-specific anchoring protein (αkap) encoded within the calcium/calmodulin-dependent protein kinase IIα (CAMK2A) gene is essential for the maintenance of AChR clusters both

Indexed as

A Kinase Anchor ProteinsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Dystrophin-Associated ProteinsHEK293 CellsHeLa CellsHumansMiceMultiprotein ComplexesNeuropeptidesProtein DomainsProtein StabilityReceptors, CholinergicA Kinase Anchor ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mouseDtna protein, mouseDystrophin-Associated ProteinsMultiprotein ComplexesNeuropeptidesReceptors, CholinergicAChRagrin-induced AChR clustersHEK cellsimaginginteractionmuscle-specific anchoring proteinmyotubesnicotinic acetylcholine receptors (nAChR)phosphorylationphosphorylation of α-dystrobrevinproteasome inhibitorprotein complexprotein degradationprotein phosphorylationprotein stabilitystabilitystability of αkapα-dystrobrevinαkap

Identifiers

PMID32532815
PMCPMC7397092
OpenAlexW3034511488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.