Evidence map›Paper›PMID 32532796›Full record

ArticleThe Journal of biological chemistry2020

A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice.

Andrei V Chernov, Swathi K Hullugundi, Kelly A Eddinger, Jennifer Dolkas, Albert G Remacle, Mila Angert, Brian P James, Tony L Yaksh, Alex Y Strongin, Veronica I Shubayev

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  5. Pain kept under wraps of myelin sheath.Frontiers in pain research (Lausanne, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Andrei V ChernovDepartment of Anesthesiology, University of California, San Diego, La Jolla, California, USA achernov@ucsd.edu vshubayev@ucsd.edu.
Swathi K HullugundiDepartment of Anesthesiology, University of California, San Diego, La Jolla, California, USA.
Kelly A EddingerDepartment of Anesthesiology, University of California, San Diego, La Jolla, California, USA.
Jennifer DolkasDepartment of Anesthesiology, University of California, San Diego, La Jolla, California, USA.
Albert G RemacleInfectious & Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Mila AngertDepartment of Anesthesiology, University of California, San Diego, La Jolla, California, USA.
Brian P JamesInfectious & Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Tony L YakshDepartment of Anesthesiology, University of California, San Diego, La Jolla, California, USA.
Alex Y StronginInfectious & Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.ORCID 0000-0003-3765-3016
Veronica I ShubayevDepartment of Anesthesiology, University of California, San Diego, La Jolla, California, USA achernov@ucsd.edu vshubayev@ucsd.edu.ORCID 0000-0003-2598-263X
University of California San Diego · USSanford Burnham Prebys Medical Discovery Institute · US

Funding

Proteolysis of Myelin as a Source of Neuropathic PainR01DE022757 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHUBAYEV, VERONICA · 2012 to 2022
$7.3M
BLRD VA I01 BX000638NIDCR NIH HHS R01 DE022757
6 · The paper itself

Abstract

In the peripheral nerve, mechanosensitive axons are insulated by myelin, a multilamellar membrane formed by Schwann cells. Here, we offer first evidence that a myelin degradation product induces mechanical hypersensitivity and global transcriptomics changes in a sex-specific manner. Focusing on downstream signaling events of the functionally active 84-104 myelin basic protein (MBP(84-104)) fragment released after nerve injury, we demonstrate that exposing the sciatic nerve to MBP(84-104) via endoneurial injection produces robust mechanical hypersensitivity in female, but not in male, mice. RNA-seq and systems biology analysis revealed a striking sexual dimorphism in molecular signatures of the dorsal root ganglia (DRG) and spinal cord response, not observed at the nerve injection site. Mechanistically, intra-sciatic MBP(84-104) induced phospholipase C (PLC)-driven (females) and phosphoinositide 3-kinase-driven (males) phospholipid metabolism (tier 1). PLC/inositol trisphosphate receptor (IP3R) and estrogen receptor co-regulation in spinal cord yielded Ca

Indexed as

Calcium SignalingRNA-SeqSex CharacteristicsTranscriptomeAnimalsFemaleGanglia, SpinalInositol 1,4,5-Trisphosphate ReceptorsMaleMiceMyelin Basic ProteinNeuralgiaPeptide FragmentsSciatic NerveType C PhospholipasesInositol 1,4,5-Trisphosphate ReceptorsItpr1 protein, mouseMyelin Basic Proteinmyelin basic protein 84-104Peptide FragmentsType C Phospholipasesanalgesiachronic paindorsal root gangliaMBP(84-104)mechanical allodyniamyelinmyelin basic proteinneuroinflammationneuropathic painpainRNA-seqsexual dimorphismsystems biologytranscriptomics

Identifiers

PMID32532796
PMCPMC7397096
OpenAlexW3034882257

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.