Evidence map›Paper›PMID 32532771›Full record

ArticleBMJ open2020

Economic evaluation of surgical treatments for women with stress urinary incontinence: a cost-utility and value of information analysis.

Mehdi Javanbakht, Eoin Moloney, Miriam Brazzelli, Sheila Wallace, Laura Ternent, Muhammad Imran Omar, Ash Monga, Lucky Saraswat, Phil Mackie, Frauke Becker and 6 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Mehdi JavanbakhtPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-8661-8439
Eoin MoloneyPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK eoin.moloney@newcastle.ac.uk.ORCID 0000-0002-3025-5413
Miriam BrazzelliHealth Services Research Unit, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-7576-6751
Sheila WallacePopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Laura TernentPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Muhammad Imran OmarAcademic Urology Unit/Cochrane Incontinence Group, University of Aberdeen, Aberdeen, UK.
Ash MongaGynaecology, University Hospitals Southampton Foundation Trust, Southampton, UK.
Lucky SaraswatObstetrics and Gynaecology, Aberdeen Royal Infirmary, Aberdeen, UK.
Phil MackieScottish Public Health Network, NHS Health Scotland, Glasgow, UK.
Frauke BeckerHealth Economics Research Centre, University of Oxford, Oxford, UK.
Mari ImamuraHealth Services Research Unit, University of Aberdeen, Aberdeen, UK.
Jemma HudsonHealth Services Research Unit, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-6440-6419
Michal ShimonovichHealth Services Research Unit, University of Aberdeen, Aberdeen, UK.
Graeme MacLennanHealth Services Research Unit, University of Aberdeen, Aberdeen, UK.ORCID 0000-0002-1039-5646
Luke ValePopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Dawn CraigPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Newcastle University · GBUniversity of Aberdeen · GBAberdeen Royal Infirmary · GBPublic Health Scotland · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Oxford · GB

Funding

Chief Scientist Office HSRU1Medical Research Council MR/K02325X/1
6 · The paper itself

Abstract

objectivesStress urinary incontinence (SUI) and stress-predominant mixed urinary incontinence (MUI) are common conditions that can have a negative impact on the quality of life of patients and serious cost implications for healthcare providers. The objective of this study was to assess the cost-effectiveness of nine different surgical interventions for treatment of SUI and stress-predominant MUI from a National Health Service and personal social services perspective in the UK.

methodsA Markov microsimulation model was developed to compare the costs and effectiveness of nine surgical interventions. The model was informed by undertaking a systematic review of clinical effectiveness and network meta-analysis. The main clinical parameters in the model were the cure and incidence rates of complications after different interventions. The outcomes from the model were expressed in terms of cost per quality-adjusted life-years (QALYs) gained. In addition, expected value of perfect information (EVPI) analyses were conducted to quantify the main uncertainties facing decision-makers.

resultsThe base-case results suggest that retropubic mid-urethral sling (retro-MUS) is the most cost-effective surgical intervention over a 10-year and lifetime time horizon. The probabilistic results show that retro-MUS and traditional sling are the interventions with the highest probability of being cost-effective across all willingness-to-pay thresholds over a lifetime time horizon. The value of information analysis results suggest that the largest value appears to be in removing uncertainty around the incidence rates of complications, the relative treatment effectiveness and health utility values.

conclusionsAlthough retro-MUS appears, at this stage, to be a cost-effective intervention, research is needed on possible long-term complications of all surgical treatments to provide reassurance of safety, or earlier warning of unanticipated adverse effects. The value of information analysis supports the need, as a first step, for further research to improve our knowledge of the actual incidence of complications.

Indexed as

Suburethral SlingsUrinary Incontinence, StressUrologic Surgical ProceduresCost-Benefit AnalysisFemaleHumansMarkov ChainsModels, EconomicNetwork Meta-Analysis as TopicQuality-Adjusted Life YearsSystematic Reviews as TopicTreatment OutcomeUnited Kingdomadult surgeryhealth economicsurinary incontinences

Identifiers

PMID32532771
PMCPMC7295417
OpenAlexW3034826900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.