Evidence map›Paper›PMID 32532764›Full record

ReviewThe British journal of ophthalmology2021

COVID-19 and immunosuppression: a review of current clinical experiences and implications for ophthalmology patients taking immunosuppressive drugs.

Zheng Xian Thng, Marc D De Smet, Cecilia S Lee, Vishali Gupta, Justine R Smith, Peter J McCluskey, Jennifer E Thorne, John H Kempen, Manfred Zierhut, Quan Dong Nguyen and 2 more

Open access · bronzeAbstract readReview
In one paragraph

Review in The British journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

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  14. Undiagnosed Behçet's Disease Complicated by Multiple Pseudoaneurysms and COVID-19 Infection.The International journal of angiology : official publication of the International College of Angiology, Inc · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 7 countries.

Zheng Xian ThngDepartment of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.ORCID 0000-0003-3275-7537
Marc D De SmetOphthalmology, MIOS, Lausanne, Switzerland.ORCID 0000-0002-9217-5603
Cecilia S LeeOphthalmology, University of Washington, Seattle, Washington, USA.
Vishali GuptaDepartment of Ophthalmology, Postgraduate Institute of Medical Education and Research, Advanced Eye Centre, Chandigarh, India.
Justine R SmithCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0002-4756-5493
Peter J McCluskeyDepartment of Medical Retina and Uveitis, Sydney Eye Hospital, Sydney, New South Wales, Australia.
Jennifer E ThorneDivsion of Ocular Immunology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, USA.
John H KempenDepartment of Ophthalmology, Massachusetts Eye and Ear and Harvard Medical School, Boston, Massachusetts, USA.
Manfred ZierhutUniversity of Tuebingen, Tubingen, Germany.
Quan Dong NguyenByers Eye Institute, Stanford University, Palo Alto, California, USA.
Carlos PavesioDepartment of Medical Retina and Uveitis, Moorfields Eye Hospital NHS Foundation Trust, London, London, UK.
Rupesh AgrawalDepartment of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore rupesh_agrawal@ttsh.com.sg.ORCID 0000-0002-6662-5850
Moorfields Eye Hospital NHS Foundation Trust · GBFlinders University · AUMassachusetts Eye and Ear Infirmary · USPost Graduate Institute of Medical Education and Research · INSmith-Kettlewell Eye Research Institute · USSydney Hospital · AUTan Tock Seng Hospital · SGUniversity of Tübingen · DEUniversity of Washington · US

Funding

Aging eyes and aging brains in studying alzheimer's disease: Modern ophthalmic data collection in the adult changes in thought (ACT) studyR01AG060942 · NIA · WASHINGTON UNIVERSITY · PI Cecilia Sungmin Lee · 2019 to 2026
$39.4M
NIA NIH HHS R01 AG060942
6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in Wuhan city, Hubei province, China. This is the third and largest coronavirus outbreak since the new millennium after SARS in 2002 and Middle East respiratory syndrome (MERS) in 2012. Over 3 million people have been infected and the COVID-19 has caused more than 217 000 deaths. A concern exists regarding the vulnerability of patients who have been treated with immunosuppressive drugs prior or during this pandemic. Would they be more susceptible to infection by the SARS-CoV-2 and how would their clinical course be altered by their immunosuppressed state? This is a question the wider medical fraternity-including ophthalmologists, rheumatologists, gastroenterologist and transplant physicians among others-must answer. The evidence from the SARS and MERS outbreak offer some degree of confidence that immunosuppression is largely safe in the current COVID-19 pandemic. Preliminary clinical experiences based on case reports, small series and observational studies show the morbidity and mortality rates in immunosuppressed patients may not differ largely from the general population. Overwhelmingly, current best practice guidelines worldwide recommended the continuation of immunosuppression treatment in patients who require them except for perhaps high-dose corticosteroid therapy and in patients with associated risk factors for severe COVID-19 disease.

Indexed as

COVID-19Eye DiseasesHumansImmunosuppression TherapyImmunosuppressive AgentsOphthalmologyPharmaceutical PreparationsPractice Guidelines as TopicSARS-CoV-2Immunosuppressive AgentsPharmaceutical Preparationsdrugsimmunologyinflammation

Identifiers

PMID32532764
PMCPMC7316101
OpenAlexW3034395824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.