ArticleBMC complementary medicine and therapies2020
Altitude impact on the chemical profile and biological activities of Satureja thymbra L. essential oil.
Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 57 citations in OpenAlex.
- Current Knowledge of the GenusPharmaceuticals (Basel, Switzerland) · 2026Review
- A Review of Essential Oils with Anti-Foods (Basel, Switzerland) · 2026Review
- Antibacterial, Antioxidant Potential, and Chemodiversity of Aesculus indica Bark Extracts Along the Garhwal Himalayan Altitudinal Gradient.Chemistry & biodiversity · 2026Article
- Exploring Chemical Variability in the Essential Oil of Artemisia absinthium L. in Relation to Different Phenological Stages and Geographical Location.Chemistry & biodiversity · 2025Article
- Chemical Composition, Acetylcholinesterase-Inhibitory Potential and Antioxidant Activity of Essential Oils from Three Populations ofMolecules (Basel, Switzerland) · 2025Article
- Antibacterial Activity of Selected Essential Oil Components and Their Derivatives: A Review.Antibiotics (Basel, Switzerland) · 2025Review
- Spatial distribution characteristics and pollution evaluation of soil heavy metals in Wulongdong National Forest Park.Scientific reports · 2024Article
- A Nano-Based Approach to DeliverMolecules (Basel, Switzerland) · 2024Article
- Elevation determines the productivity of large cardamom (Amomum subulatum Roxb.) cultivars in Sikkim Himalaya.Scientific reports · 2023Article
- Effects of altitudes on secondary metabolite contents of Origanum majorana L.Scientific reports · 2023Article
- Major phenolic compounds, antioxidant, antimicrobial, and cytotoxic activities ofFrontiers in nutrition · 2023Article
- Untargeted metabolomics approach and molecular networking analysis reveal changes in chemical composition under the influence of altitudinal variation in bamboo species.Frontiers in molecular biosciences · 2023Article
- Natural essential oils as a new therapeutic tool in colorectal cancer.Cancer cell international · 2022Review
- Chemical Constituents, In Vitro Antioxidant Activity and In Silico Study on NADPH Oxidase ofAntioxidants (Basel, Switzerland) · 2021Article
- Impact of Altitudinal Variation on the Phytochemical Profile, Anthelmintic and Antimicrobial Activity of TwoMolecules (Basel, Switzerland) · 2021Article
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral agricultural or environmental factors affect plants' chemical and pharmacological properties.
methodsIn this study, the essential oil of Libyan Satureja thymbra was isolated from plants collected during two successive years at two different altitudes; Wasita (WEO) and Safsaf (SEO), 156 and 661 m above sea level, respectively.
resultsGC/MS allowed the identification of 21 and 23 compounds, respectively. Thymol prevailed in WEO (26.69%), while carvacrol prevailed in SEO (14.30%). Antimicrobial activity was tested by agar-well diffusion method, and MIC/MLC values were determined by broth dilution method. Values of MIC/MLC were 0.125/0.25 μg/ml for SEO against S. aureus, P. mirabilis and K. pneumonia and for WEO against B. subtilus. It was observed that plants growing at lower altitude in Wasita locality had better antifungal activity, while those growing at higher altitude at Safsaf locality had better antibacterial activity. Both essential oils had a better anthelmintic activity than the standard piperazine citrate against a tested earthworm. However, SEO oil had a significantly higher anthelmintic activity than WEO. Cytotoxicity of the oils tested using SRB assay on human breast cancer (MCF-7) and colon cancer cell lines (HCT-116) showed better activity for SEO, especially against HCT-116 with IC
conclusionsThus, altitude is an important factor that should be considered as it affected the yield, composition and biology of the plant extracts.
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