ArticleBMC anesthesiology2020
Intraoperative hypotension is associated with increased postoperative complications in patients undergoing surgery for pheochromocytoma-paraganglioma: a retrospective cohort study.
Article in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- Critical illness-related corticosteroid insufficiency after acute brain hemorrhage surgery: a prospective cohort study with a randomized trial of hydrocortisone : HYdrocortisone theraPy in nEurocRitical illness; HYPER study.Critical care (London, England) · 2026Trial
- Catecholamine-induced hypertensive crisis during laparoscopic adrenalectomy for pheochromocytoma.Updates in surgery · 2026Article
- Learning curve of blood pressure management during phaeochromocytoma surgery without preoperative alpha-blockade dose escalation.Endocrine connections · 2026Article
- Intraoperative vasopressor use as a risk factor for early periprosthetic joint infection after total joint arthroplasty: A retrospective cohort study.Journal of orthopaedics · 2026Article
- Preoperative inferior vena cava ultrasound for volume optimization in resection of functioning pheochromocytoma and paraganglioma: association with perioperative adverse outcomes in a prospective observational cohort.Frontiers in endocrinology · 2026Observational
- Article
- Association of postoperative delirium with hypotension in critically ill patients after cardiac surgery: a prospective observational study.Journal of cardiothoracic surgery · 2024Observational
- Case of functional paraganglioma with intraoperative hypertensive crisis during robot-assisted thoracoscopic resection.Surgical case reports · 2024Article
- Exploration of factors affecting hemodynamic stability following pheochromocytoma resection - cohort study.Frontiers in endocrinology · 2024Article
- Abandonment of intravenous volume expansion after preoperative receipt of α-blockers in patients with adrenal pheochromocytoma was not an independent risk factor for intraoperative hemodynamic instability.Frontiers in endocrinology · 2023Article
- Bladder paraganglioma: basic characteristics and new perspectives on perioperative management.World journal of urology · 2022Article
- The association between the type of anesthesia and hemodynamic instability during pheochromocytoma surgery: a retrospective cohort study.Surgical endoscopy · 2022Article
- Characteristics of Intraoperative Hemodynamic Instability in Postoperatively Diagnosed Pheochromocytoma and Sympathetic Paraganglioma Patients.Frontiers in endocrinology · 2022Article
- Surgical outcomes in the pheochromocytoma surgery. Results from the PHEO-RISK STUDY.Endocrine · 2021Article
- Perioperative hemodynamic instability in pheochromocytoma and sympathetic paraganglioma patients.Scientific reports · 2021Article
- A Predictive Nomogram for Red Blood Cell Transfusion in Pheochromocytoma Surgery: A Study on Improving the Preoperative Management of Pheochromocytoma.Frontiers in endocrinology · 2021Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundDramatic hemodynamic fluctuation occurs frequently during surgery for pheochromocytoma or paraganglioma. However, the criteria of intraoperative hemodynamic instability vary widely, and most of them were defined arbitrarily but not according to patients' prognosis. The objective was to analyze the relationship between different thresholds and durations of intraoperative hyper-/hypotension and the risk of postoperative complications in patients undergoing surgery for pheochromocytoma or paraganglioma.
methodsThis was a retrospective single-center cohort study performed in a tertiary care hospital from January 1, 2005 to December 31, 2017. Three hundred twenty-seven patients who underwent surgery for pheochromocytoma or paraganglioma, of which the diagnoses were confirmed by postoperative pathologic examination, were enrolled. Those who were less than 18 years, underwent surgery involving non-tumor organs, or had incomplete data were excluded. The primary endpoint was a composite of the occurrence of AKI or other complications during hospital stay after surgery. Multivariate Logistic regression models were used to analyze the association between different thresholds and durations of intraoperative hyper-/hypotension and the development of postoperative complications.
resultsForty three (13.1%) patients developed complications during hospital stay after surgery. After adjusting for confounding factors, intraoperative hypotension, defined as systolic blood pressure (SBP) of ≤95 mmHg for ≥20 min (OR 3.211; 99% CI 1.081-9.536; P = 0.006), SBP of ≤90 mmHg for ≥20 min (OR 3.680; 98.8% CI 1.107-12.240; P = 0.006), SBP of ≤85 mmHg for ≥10 min (OR 3.975; 98.3% CI 1.321-11.961; P = 0.003), and SBP of ≤80 mmHg for ≥1 min (OR 3.465; 95% CI 1.484-8.093; P = 0.004), were associated with an increased risk of postoperative complications. On the other hand, intraoperative hypertension was not significantly associated with the development of postoperative complications.
conclusionsFor patients undergoing surgery for pheochromocytoma or paraganglioma, intraoperative hypotension is associated with increased postoperative complications; and the harmful effects are level- and duration-dependent. The effects of intraoperative hypertension need to be studied further.
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